PURDUE
UNIVERSITY
Lab
of Immunology & Hematopoiesis
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Major Research Interests:
Cell
trafficking and function in the hematolymphoid system
Education:
1986-1990,
B.S., Korea Advanced Institute of Science and
Technology, Biology
1990-1992,
M.S., Korea Advanced Institute of Science and
Technology, Biotechnology
1995-1998,
PhD, Indiana University School of Medicine,
Immunology
Postdoctoral Training:
1998-1999
Postdoctoral Fellow, Indiana University School of
Medicine
1999-2002
Postdoctoral Fellow, Stanford University School of
Medicine
Appointments:
1992-1995
Research Scientist, LG Chem. LTD
1995-1998
Instructor,
Microbiology and Immunology, Indiana University School of Medicine
2002-2006
Assistant Professor of Immunology, Department of Comparative
Pathobiology and Purdue Cancer Center; Purdue University
2006-present Associate Professor
of Immunology (tenured), Department of Comparative Pathobiology and
Purdue Cancer Center
2008-2013 University
Faculty Scholar, Purdue University
Awards and Honors:
1998
Rudell/Wright Scholarship, Walther Cancer
Institute
1998
Presidential Award, Society for
Leukocyte Biology
1999-2002 Leukemia and
Lymphoma Society Fellow
2002-2005 Leukemia and
Lymphoma Society Special Fellow
2003
New Investigator Award, Leukemia
Research Foundation
2005-2007 Sidney Kimmel
Scholar, Sidney Kimmel Foundation for Cancer Research
2005
Pfizer Showell Travel Award,
American Association of Immunologists
2006
Pfizer Research Award of
Excellence
2007-2010 Crohn’s and
Colitis Foundation Senior Investigator
2008
Seeds for Success Award, Purdue
University
Editorial Boards:
2004
Guest Editor for Current Medicinal Chemistry - Anti
Inflammatory & Anti Allergy Agents,
2005- present Editorial Advisory Board Member,
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
2008- present Editor-In-Chief, Cytokines and Chemokines
(will be launched in late 2008 )
Memberships and Committee Assignments in Professional Societies:
Selected Lectures:
1. The
chemokine CK beta-11/MIP-3 beta/ELC is an efficacious chemoattractant
for T- and Bcells. American Society of Hematology, San Diego, December
1997.
2. CK
beta-11/MIP-3 beta/ELC, a CC chemokine, is a chemoattractant for
myeloid progenitor cells with a specificity for granulo-monocytic
progenitors: Comparison with CXC chemokine
SDF-1. American Society of Hematology, San Diego, December 1998.
3. SHIP
is a key regulator of chemokine-induced biological effects and
signaling, International Society of Experimental Hematology Meeting,
Monaco, July, 1999.
4. CXCR5
expression and T cell function, KOLIS meeting, Stanford University,
Stanford, CA, May 2000.
5.
Regulation of immunity and hematopoiesis by chemokines, Yonsei
University, Seoul, Korea, 1999.
6. SHIP
regulation of chemokine responsiveness, International Society of
Experimental Hematology, Monte Carlo, 1999.
7.
Chemokine receptors and T cell effector functions, Department of
Microbiology and Immunology, Indiana University School of Medicine,
2001.
8. CXCR5
and B cell helping effector T cells, Annual meeting of American
Association of Immunologists, Orlando, April 2001.
9.
Chemokines and immune responses, G7 science symposium, Korea Advanced
Institute of Science and Technology, South Korea, December, 2001.
10.
Chemokines and humoral immune responses, Department of Microbiology,
University of Tennessee, Knoxville, 2002.
11.
Chemokine receptors and regulation of immune responses, Department of
Immunology, National Jewish Center, Denver, March 2002.
12.
Distinct NKT cell subsets, Annual Meeting of American Association of
Immunologists, New Orleans, April 2002.
13. T
cell migration and function. La Jolla Institute for Allergy and
Immunology, La Jolla, CA, 2002.
14.
Functional genomics of germinal center T cells, Department of
Chemistry, Purdue University, 2002.
15.
Cytokines and chemokines, Department of Biological Sciences, Purdue
University, 2003.
16.
Germinal center T cells. Indiana University Medical Education Center
Retreat, Lynn Hall, May 2003.
17.
Lymphocyte migration to gut. Guts Meeting, Purdue University, August
2003.
18.
Germinal center T cells and B lymphocyte chemoattractant. StN (signal
transduction to nucleus), Purdue, May 2004.
19.
Regulatory T cells programmed to home to follicles suppress T helper
activity and humoral immune responses. Keystone Symposia Meeting
(Leukocyte Trafficking: Cellular and Molecular Mechanisms), Taos, New
Mexico, March 2005.
20.
Regulatory T cells acquire migratory capacity to follicles upon T cell
activation and suppress GC-T helper cell-driven B cell responses.
American Association of Immunologists. San Diego, April, 2005.
21.
Follicular regulatory T cells. Immunology PI meeting. Indiana
University School of Medicine, Indianapolis, May 2005.
22. Mouse
models of inflammatory bowel diseases. Fourth Annual Workshop on
Pathology of Mouse Models of Human Disease. West Lafayette, August 2005.
23.
Immunology of Crohn’s disease in mice, Department of Basic Medical
Science, Purdue University, March, 2007
24. A
novel mechanism of immune regulation by vitamin A, Phi Zeta Research
Day, Purdue University School of Veterinary Medicine, April 2007
25.
Regulation of the immune system by vitamin A, a new mechanism. Pfizer
Award Recipient Presentation, Phi Zeta Research Day, School of
Veterinary Medicine, Purdue University. April, 2007.
26.
Developmental and antigen-driven trafficking receptor switches in
FoxP3+ regulatory T cells. American Association of Immunologists. Miami
Beach, May, 2007.
27. The
trafficking signals important for migration of FoxP3+ regulatory T
cells into chronically inflamed intestine. International Congress of
Mucosal Immunology, Tokyo, Japan, July, 2007
28.
Trafficking of regulatory T cells, An Adipogen and Korea University
joint seminar, Seoul, Korea, July 2007
29.
Regulation of FoxP3+ regulatory T cells by retinoids. Excellent
Biomedical Scientist Seminar Series, Seoul National University School
of Medicine. December 2007
30.
Induction and trafficking of regulatory T cells. Department Seminar.
Department of Microbiology and Immunology, Indiana University School of
Medicine, Indianapolis, February,
2008.
31.
Chemokine receptors and migration of cord blood-derived regulatory T
cells. The Sixth Annual Umbilical Cord Blood Transplantation Symposium,
June 6-7, 2008, Los Angeles
32.
Chemokine receptors and trafficking of regulatory T cells into tumors.
Era of Hope Breast Cancer Research Symposium, Baltimore (Scheduled for
late June 2008)
•
Functions of chemokines and chemokine receptors in immune cell
trafficking
• Trafficking and development of hematopoietic stem and progenitor cells
• Identification of novel homing receptors
•
Study trafficking, function and utilization of FoxP3+ regulatory T
cells in health and diseases (autoimmune diseases and cancer)
Click for more information regarding our research in the lab:
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Hromas R., Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C and Broxmeyer. HE, Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J. Immunol., 1997, 159: 2554-2558.
Kim CH and Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: SDF-1, Steel Factor and the bone marrow environment. Blood, 1998, 91:100-110.
Kim CH, Pelus LM, White JR, Appelbaum E, Johanson K, and Broxmeyer HE, CKb-11/MIP-3b/ELC is an efficacious chemoattractant for T- and B-cells. J. Immunol., 1998, 160:2418-2424.
Kim CH, Pelus LM, White JR, and Broxmeyer HE. Rapid communication: Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood, 1998, 91:4434-4443.
Kim CH, Pelus LM, White JR, and Broxmeyer HE. MIP-3b/ELC/CKb-11, a CC chemokine, is a chemoattractant for myeloid progenitor cells with a specificity for macrophage progenitors. J. Immunol., 1998, 161:2580-2585.
Broxmeyer HE and Kim CH (1999) Chemokines and hematopoiesis. In Chemokines and Cancer. B. J. Rollins, Ed. Humana Press, NJ, pp. 263-291.
Kim CH and Broxmeyer HE. Chemokines: Signal lamps for trafficking of T- and B-cells for development and effector function. 1999, J. Leukoc. Biol., 65:6-15.
Kim CH and Broxmeyer HE. (2000) Chemokines for immature blood cells: effects on migration, proliferation and differentiation. In Chemokines and Allergic Diseases. M. E. Rothenberg, Ed. Marcel Dekker, New York, NY, pp. 227-261.
Kim CH and Broxmeyer HE. Thrombopoietin and interleukin-3 are chemotactic and chemokinetic chemoattractants for a factor-dependent hematopoietic progenitor cell line. Ann N Y Acad Sci., 1999, 872:395
Kim CH and Broxmeyer HE, SLC/Exodus2/6Ckine induces chemotaxis of hematopoietic progenitor cells: Differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis vs. suppression of progenitor proliferation. 1999, J. Leukoc. Biol., 66: 455-461.
Broxmeyer HE, and Kim CH, Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. 1999, Exp. Hematol. 189:1987-92.
Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.
Youn BS, Kim CH, Smith F, Broxmeyer HE, TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. 1999, Blood. 94:2533-2536.
Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.
Braun SE, Chen SE, Foster RG, Kim CH, Hromas R, Broxmeyer, HE, Cornetta K, The CC chemokine CKb-11/MIP-3b/ELC/Exodus3 mediatesnbsp tumor rejection of murine breast cancer cells through natural killer cells. 2000, J. Immunol. 164:4025.
Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.
Andrew DP, Ruffing N, Kim CH (co-first authors), Miao A, Heath H, You-Li, Murphy K, Butcher EC, Wu L, CCR4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential. 2001, J. Immunol. 166:103.
Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.
Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.
Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.
Kim CH, Campbell DJ, and Butcher EC, Nonpolarized memory T cells. 2001, Trends in Immunology. 22:527-530.
Kim CH, Johnston Brent and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.
Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.
Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev. 2003, 195:58-71.
Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. J. Immunol. 2003, 170:421-429.
Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003, 111:1001-10.
Broxmeyer HE, Kohli L, Kim CH, Lee Y, Mantel C, Cooper S, Hangoc G, Shaheen M,nbsp Li X, Clapp DW. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Galphai proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol. 2003, 73(5):630-638.
Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. Differential chemokine responses and homing patterns of murine TCRalphabeta NKT cell subsets. J Immunol. 2003, 171:2960-9.
Kim CH, Butcher EC, Johnston B. Distinct subsets of human Va24-invariant NKT cells. 2002, Trends in Immunology, 23:516-9.
Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171(1):152-8.
Kim CH. Chemokine-chemokine receptor network in immune cell trafficking. 2004, Current Drug Target- Immune, Endocrine & Metabolic Disorders. 2004:4, 343-361.
Kim CH and Johnson R. Trafficking potentials of unconventional T cell subsets. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents. 2004, 3:321-340.
Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.
Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.
Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.
Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In Chemokines, Chemokine Receptors, and Disease. Edited by Lisa Schwiebert. Current Topics in Membranes (Elsevier. 2005), 55:115-142.
Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.
Lim, HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183.
Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.
Kim CH. Migration and function of Foxp3+ regulatory T cells in hematolymphoid system (review). Exp. Hematol. 2006, 34:1033-40.
Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.
Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868
Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.
Kang SG, Piniecki RJ, Hogenesch H, Lim HW, Wiebke E, Braun SE, Matsumoto S, Kim CH. Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology. 2007, 3: 966-81.
Kim CH. Molecular targets of FoxP3+ regulatory T cells (Review). Mini Rev Med Chem. 2007, 7:1136-43.
Lim HW, Kim CH. Loss of IL-7 Receptor alpha on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue. J Immunol. 2007, 179:7448-56.
Kim CH. Trafficking of FoxP3+ regulatory T cells: myths and facts. Arch Immunol Ther Exp (Review). 2007, 55:151-9.
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007, 179(6):3724-33.
Kim CH. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis (Chapter 8). In The Chemokine Receptors. Harrison and Lukacs. Ed. Humana Press, NJ, 2007, p119-138.
Lim HW,
Lee J, Hillsamer P, Kim CH. Human Th17
cells share major trafficking receptors with both polarized effector T
cells and FOXP3+ regulatory T cells.
J Immunol. 2008 Jan 1;180(1):122-9.
Postdoctoral
Fellowship and Graduate Training Opportunities:
Opportunities are available in several
research areas, including but not limited to:
• Trafficking and development of
hematopoietic
stem and progenitor cells
• Functional genomics of T cell
differentiation
• Chemokines and chemokine receptor
in regulation of leukocyte trafficking and immune responses
• Generation of knock out/in mice and
in vivo tracking of leukocyte migration
Individuals with a record of productivity and relevant experience in cell and molecular biology and/or immunology are encouraged to apply. Send Curriculum vitae and references to: Chang H. Kim, 1243 VPTH, Purdue University, West Lafayette, IN 47907-1243 (chkim@purdue.edu). Phone: 765-494-0976 (Office), Fax: 765-494-9830.
Last Revised: January 2008
