Engineering Nanomedical Systems

This is the course website for BME695 Engineering Nanomedical Systems for the Fall 2011 semester.

Latest copy of course syllabus (version 10/4/2011) see changes! NEW

First Assignment (8/23/2011)

Lecture 1: The need for nanomedicine (August 23, 2011)
   Lecture outline
   PowerPoint presentation

References:
Leary CJO paper
Haglund-Seale-Leary paper
Seale-Leary Nanobiosystems paper

Lecture 2: Designing nanomedical systems (August 25, 2011)
Lecture outline
PowerPoint presentation

References:
Ahn 2007 paper
McCarthy et al 2007 paper
Pan et al 2008 paper
Prow et al 2005 paper

Lecture 3: Theragnostics and molecular imaging (August 30, 2011)
Lecture outline
PowerPoint presentation

References:
Langer group paper 2004
Ruoslahti group paper 2002
Nie group paper 2004
Weissleder group paper 2005
de las Fuente paper 2006
Cai and Chen paper 2007
Baozhong et al paper 2011

Paper 1 Review:
Paper 1 review guidelines
Paper 1 PDF copy

Project:
Project guidelines
Sample Project

Lecture 4: Targeting (on September 8, 2011)
Lecture outline
PowerPoint presentation

References:
Leary Rare cells 1994
Leary HS Sorting 2005
Rosenblatt Rare sampling statistics 1997
Prow et al 2004
Szaniszlo et al LEAP 2006
von Maltzahn Click Chemistry 2008
McCarron et al Antibody targeting 2008
Yang et al Aptamer synthesis 2003
Yang et al. Aptamer screeing 2003
Lu and Low Folate receptors 2002
Shapiro Practical Flow Cytometry:
http://www.beckmancoulter.com/wsrportal/wsr/research-and-discovery/products-and-services/flow-cytometry/practical-flow-cytometry/index.htm

Lecture 5: Core Materials (on September 13, 2011)
Lecture outline
PowePoint presentation

References:
Burda et al. 2005
Mornet et al. 2004
Osaka et al. 2006
Park et al. 2000
Wang et al. 2006
Cooper et al. ( http://docs.lib.purdue.edu/cgi/viewcontent.cgi?article=1021&context=nanoposter )
Yu et al. 2004
Lu et al. 2007
Slowing et al., 2007

Lecture 6: Cell entry (on September 15, 2011)
Lecture outline
PowerPoint presentation

References:
Chithrani et al 2006 paper
Xiao et al 2010 paper
Zhang and Monteiro-Riviere 2009 paper
Xia et al 2009 paper
Krpetic et al 2011 paper
Guo and Huang 2011 paper
Schmaljohann 2006 paper

Lecture 7: Zeta potential (on September 20, 2011)
Lecture outline
PowerPoint presentation

References:

Prow et al. 2005 paper
Zhang et al 2008 paper

Lecture 8: Surface conjugation chemistry (on September 22, 2011)
Lecture outline
PowerPoint presentation

References:
Bagwe et al paper
Derfus et al paper
Hwu et al paper
Kang et al paper
Wang et al Qdot paper
Yu et al paper

Lecture 9: Challenges of Drug Dosing (on September 27, 2011)
Lecture outline
PowerPoint presentation

References:
Adams and Weiner paper
Baber and Pritchard paper
Bailey and Haddad paper
McCoy et al paper
Miller paper
Wajima et al paper
Thomas et al paper

Lecture 10: Gene Delivery (on September 29, 2011)
Lecture outline
PowerPoint presentation

References:
Fahmy et al paper
Jabr-Milane et al paper
Prow et al 2004 JMH paper
Prow et al 2004 SPIE paper
Prow et al 2005 SPIE paper
Prow et al Mol Vis 2006 first paper
Prow et al Mol Vis 2006 second paper
Jin and Ye paper
Groth et al paper
Bertoni et al paper
Dobson paper


Paper 2 Review:
Paper 2 review guidelines
Paper 2 PDF copy

Lecture 11: Nanotoxicity (on October 4, 2011)
Lecture outline
PowerPoint presentation

References:
Chan 2005 paper
Chan 2006 paper
Darzynkiewicz paper
Kirchner paper
Monteiro-Riviere paper
Oberdoerster paper

Lecture 12: Efficacy (on October 25, 2011)
Lecture outline
PowerPoint presentation

References:
Chan et al 2005 paper
Krutzik et al 2004 paper
Szaniszlo et al 2004 paper

Paper 3 Review:
Paper 3 review guidelines
Paper 3 PDF copy

Lecture 13: Designing in-vivo NMS (on November 1, 2011)
Lecture outline
PowerPoint presentation

References:
Bhirde et al 2009 paper
Cartier et al 2007 paper
Cheng et al 2007 paper
Farokhzad 2006 paper
Hou 2009 paper

Lecture 14: Designing and testing integrated NMS (on November 3, 2011)
Lecture outline
PowerPoint presentation

References:
Haglund et al. 2009 paper
Seale and Leary 2009 paper

Lecture 15: GMP (on November 8, 2011)
Lecture outline
PowerPoint presentation

Lecture 16: FDA, EPA, and NIOSH (on November 10, 2011)
Lecture outline
PowerPoint presentation