Lab of Immunology & Hematopoiesis
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Major Research Interests:
Cell trafficking and function in
the hematolymphoid system
Education and Trainings:
Advanced Institute of Science and Technology, Biology
M.S., Korea Advanced Institute of Science and Technology, Biotechnology
Research Scientist, LG Chem. LTD
PhD, Indiana University School of Medicine, Immunology/Hematopoiesis
Postdoctoral Fellow, Stanford University School of Medicine
Awards and Honors:
Rudell/Wright Scholarship, Walther
1998 Presidential Award, Society for Leukocyte Biology
1999-2002 Leukemia and Lymphoma Society Fellow
2002-2005 Leukemia and Lymphoma Society Special Fellow
2003 New Investigator Award, Leukemia Research Foundation
2005-2007 Sidney Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research
2005 Pfizer Showell Travel Award, American Association of Immunologists
2006 Pfizer Research Award of Excellence
2007-2010 Crohn’s and Colitis Foundation Senior Investigator
2008-2013 Purdue University Faculty Scholar
2008, 2010 Seed for Success Award, Purdue University
2010 Entrepreneurial Leadership Academy Fellow
2010 Entrepreneurial Leadership Academy Fellow
2012 PVM Research Award of Excellence, Purdue University
Memberships and Service:
Click for more information regarding our research in the lab:
Kim CH and Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: SDF-1, Steel Factor and the bone marrow environment. Blood, 1998, 91:100-110.
Kim CH, Pelus LM, White JR, Appelbaum E, Johanson K, and Broxmeyer HE, CKb-11/MIP-3b/ELC is an efficacious chemoattractant for T- and B-cells. J. Immunol., 1998, 160:2418-2424.
Kim CH, Pelus LM, White JR, and Broxmeyer HE. Rapid communication: Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood, 1998, 91:4434-4443.
Kim CH, Pelus LM, White JR, and Broxmeyer HE. MIP-3b/ELC/CKb-11, a CC chemokine, is a chemoattractant for myeloid progenitor cells with a specificity for macrophage progenitors. J. Immunol., 1998, 161:2580-2585.
Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.
Youn BS, Kim CH, Smith F, Broxmeyer HE, TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. 1999, Blood. 94:2533-2536.
Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.
Braun SE, Chen SE, Foster RG, Kim CH, Hromas R, Broxmeyer, HE, Cornetta K, The CC chemokine CKb-11/MIP-3b/ELC/Exodus3 mediatesnbsp tumor rejection of murine breast cancer cells through natural killer cells. 2000, J. Immunol. 164:4025.
Andrew DP, Ruffing N, Kim CH (co-first authors), Miao A, Heath H, You-Li, Murphy K, Butcher EC, Wu L, CCR4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential. 2001, J. Immunol. 166:103.
Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.
Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.
Kim CH, Johnston Brent and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.
Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.
Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. J. Immunol. 2003, 170:421-429.
Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003, 111:1001-10.
Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. Differential chemokine responses and homing patterns of murine TCRalphabeta NKT cell subsets. J Immunol. 2003, 171:2960-9.
Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171(1):152-8.
Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.
Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.
Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.
Lim, HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183.
Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.
Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.
Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.
Kang SG, Piniecki RJ, Hogenesch H, Lim HW, Wiebke E, Braun SE, Matsumoto S, Kim CH. Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology. 2007, 3: 966-81.
Lim HW, Kim CH. Loss of IL-7 Receptor alpha on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue. J Immunol. 2007, 179:7448-56.
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007, 179(6):3724-33.
Lim HW, Lee J, Hillsamer P, Kim
CH. Human Th17 cells share major trafficking receptors with
both polarized effector T cells and FOXP3+ regulatory T
J Immunol. 2008 Jan 1;180(1):122-9.
Wang C, Kang SG, Lee J, Sun Z, Kim CH.
The roles of CCR6 in migration of Th17 cells and
regulation of effector T-cell balance in the gut. Mucosal
Immunol. 2009 Mar;2(2):173-83
Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.
Broxmeyer HE and Kim CH (1999) Chemokines and hematopoiesis. In Chemokines and Cancer. B. J. Rollins, Ed. Humana Press, NJ, pp. 263-291.
Kim CH and Broxmeyer HE. (2000) Chemokines for immature blood cells: effects on migration, proliferation and differentiation. In Chemokines and Allergic Diseases. M. E. Rothenberg, Ed. Marcel Dekker, New York, NY, pp. 227-261.
Broxmeyer HE, and Kim CH, Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. 1999, Exp. Hematol. 189:1987-92.
Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.
Kim CH, Campbell DJ, and Butcher EC, Nonpolarized memory T cells. 2001, Trends in Immunology. 22:527-530.
Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev. 2003, 195:58-71.
Kim CH, Butcher EC, Johnston B. Distinct subsets of human Va24-invariant NKT cells. 2002, Trends in Immunology, 23:516-9.
Kim CH. Chemokine-chemokine receptor network in immune cell trafficking. 2004, Current Drug Target- Immune, Endocrine & Metabolic Disorders. 2004:4, 343-361.
Kim CH and Johnson R. Trafficking potentials of unconventional T cell subsets. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents. 2004, 3:321-340.
Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.
Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In Chemokines, Chemokine Receptors, and Disease. Edited by Lisa Schwiebert. Current Topics in Membranes (Elsevier. 2005), 55:115-142.
Kim CH. Migration and function of Foxp3+ regulatory T cells in hematolymphoid system (review). Exp. Hematol. 2006, 34:1033-40.
Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868
Kim CH. Molecular targets of FoxP3+ regulatory T cells (Review). Mini Rev Med Chem. 2007, 7:1136-43.
Kim CH. Trafficking of FoxP3+ regulatory T cells: myths and facts. Arch Immunol Ther Exp (Review). 2007, 55:151-9.
Kim CH. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis (Chapter 8). In The Chemokine Receptors. Harrison and Lukacs. Ed. Humana Press, NJ, 2007, p119-138.
Kim CH. Roles of retinoic
acid in induction of immunity and immune tolerance.
Endocr Metab Immune Disord Drug Targets. 2008
Regulation of FoxP3 regulatory T cells and Th17
cells by retinoids. Clin Dev Immunol. 2008,
Kim CH. Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. Immunol Cell Biol. 2009 Oct;87(7):502-4.
Kim CH. Migration and function of Th17 cells. Inflamm Allergy Drug Targets. 2009 Jul;8(3):221-8 (Review).
Kim CH. Trafficking Receptors and Migration of Th17 Cell Subsets. In TH17 Cells in Health and Disease (Ed. Shuiping Jiang). 2010. Springer, New York.
Kim CH. The Gastrointestinal Immune System. Comprehensive Toxicology 2nd Edition. (Ed. Charlene McQueen). 2010. Oxford: Elsevier (Textbook Chapter).
Kim CH. FOXP3 and its role in the immune system. Adv. Exp. Med. 665 17-29, 2010.
Kim CH. Retinoic acid, immunity, and inflammation. Vitam Horm. 2011;86:83-101.
Qualifications for postdoctoral fellows:
Postdoctoral Fellowship and Graduate Training Opportunities:
• Significant levels of research experience with a record of publication is preferred
• High creativity, motivation, and work ethic
• GRE and TOEFL (http://www.vet.purdue.edu/cpb/graduate-programs.php)
• Functional levels of writtern and spoken English
Individuals with a
record of productivity and relevant experience in cell and
molecular biology and/or immunology are encouraged to
Send curriculum vitae to Dr. Kim (email@example.com).
Last Revised: May 2013