PRINCIPLES OF HUMAN IMMUNOLOGY
LCME 514
Purdue University/IU School of Medicine
Spring 2008 Schedule


Instructors
Course Description
Course Objectives
Course Organization
GRADING
IMMUNOLOGY CORE  2008
Oral presentation
Readings
Lecture Schedule
Lecture Slides
Competencies Addressed 
 Text Books and References
Exams
Oral reports
Expert Clinical Immunologists
Kim Lab Home Page



 



Instructors*:

Chang Kim, PhD; chkim@purdue.edu; Office: VPTH 126; Phone: 494-0976 (Professor of Record)

Harm HogenEsch, DVM, PhD; hogenesch@purdue.edu; office VPTH 102; Phone: 494-0596

Gina Kreisle, MD, PhD, rkreisle@purdue.edu; office: VPRB G24; Phone: 494-7597
 
  *Office hours:  Students are encouraged to send emails to the instructors to set up appointments if necessary.



Course Description
LCME 514 Principle of Human Immunology (2 cr.) Limited to medical students only. An overview of the fundamental concepts of human immunology. Focuses on the interactions between the host and microbial pathogens and on mechanisms that underlie hypersensitivity reactions, autoimmune diseases and immune deficiencies. Discusses the principles of vaccination and tumor immunology.
 

 



Course Objectives
Through lectures and student participation, this course will:
1) teach molecular and cellular bases of immune responses;
2) discuss the involvement of the immune system in human diseases;
3) teach how immune responses are regulated.
 
 
 



Course Organization
Credits:  PU = 2 cr.; IU = 2 cr.
Semester/Year:  Spring 2007
Contact hours per week:  2-4  hr. lecture
Total ~32 contact hours
 

 



Competencies Addressed
Designed to develop proficiency for:

Competency III-Using Science to Guide Diagnosis, Management, Therapeutics, and Prevention
Competency IV - Livelong Learning - Level 1.
 
 
 
 



Class Room and Time
The first year class room, Lynn Hall.

Class times vary (please see the schedule for each lecture)
 
 
 
 



Required Text Book:
The Immune System, by Peter Parham, 2nd Edition, Garland Publishing Company
 

Additional References (optional)
Abbas et al. Cellular and Molecular Immunology, 5th Ed, Saunders
In addition, you will need a Board Review book of your choice.
(e.g. Levinson et al. Medical Microbiology and Immunology, McGraw-Hill)
 


Exams:
Three exams:  Exam I, exam II and statewide exam


Oral presentation (summary of lecture highlights)

A student each lecture will summarize the last lecture’s highlights for 5 minutes and take questions from other students. Pick one or two points, and do not try to present broadly.

 

Expert clinical immunologists

Each student should pick a disease of the immune system (a list will be given) and present for 5 minutes at the end of the semester (4/18/07) as if he or she is an expert clinical immunologist on the disease. This presentation accounts for 10% of the final grade.


 



Course Schedule (click for lecture slides)

Lecture/

Activity

Date

Time

Topic

Instructor*

Reading (Parham)

Slides

L1

2/27

9:00 – 10:00

 

Introduction &

Innate Immunity-phagocytes/NK cells

CK

Chapter 1, 8

Innate & Adaptive

L2

2/27

10:00–11:00

Introduction to acquired immunity

CK

Chapter 1, 3

 

L3

3/5

1:00 – 2:00

Cells involved in the immune responses, Hematopoiesis,

Lymphoid organs

Lymphocyte trafficking

 

CK

Chapter 1

Cells and organs

L4

3/5

2:00 – 3:00

Major Histocompatibility Complex

CK

Chapter 3, 5

 

L5,6

3/7

1:00 – 3:00

Antigens &Antibody I

HH

Chapter 2

Ag & Ab

L7

3/17

1:30 – 2:30

Antigens &Antibody II &

B lymphocyte I

HH

Chapter 4

B cells

L8

3/17

2:30 – 3:30

B lymphocyte II

 

HH

Chapter 4, 7

 

L9

3/21

1:00 – 2:00

Antibody-mediated immune (humoral) response

HH

Chapter 7

Humoral

L10

3/21

2:00 – 3:00

Antibody-mediated immune (humoral) response

HH

Chapter 7

 

L11

3/26

1:00 – 2:00

T lymphocyte I

CK

Chapter 3

T cell I

L12

3/26

2:00 – 3:00

T lymphocyte II and Regulation and termination of immune responses

CK

Chapter 8

 T cell II

 

3/28

1:00 – 3:00

Exam I

CK

 

 

L13,14

4/2

1:00 – 3:00

Cytokines and Inflammation

GK

Chapter 6, 8

Handout

L15,16

4/4

1:00 – 3:00

Complement/Feedback

HH

Chapter 7

Complement

L17,18

4/7

1:30 – 3:30

Type I,  II and III Hypersensitivity

 

HH

Chapter 10

Hyper1-3

L19,L20

4/9

1:00 – 3:00

Type IV Hypersensitivity

Autoimmunity/Feedback

CK

Chapter 10, 11

Hyper 4 &Auto

L21

4/11

1:00 – 2:00

Cutaneous and Mucosal Immune systems

Immunomodulation/Vaccine

CK

Chapter 12

Vaccine

L22

4/11

2:00 – 3:00

Human Blood Group Antigens

Transplantation immunology

CK

Chapter 12

Transplantation

L23

4/14

1:30 – 2:30

Tumor Immunology

CK

Chapter 12

Tumor Immunology

L24

4/14

2:30 – 3:30

Immunodeficiency

Pregnancy Immunology

Immunity in the Elderly

CK

Chapter 9

Immunodeficiency

A1

4/16

1:00 – 3:00

Interpretation of clinical immunology data

GK

 

NA

A2

4/18

1:00 – 3:00

Experts in Clinical Immunology

CK

 

NA

 

4/21

1:30 – 3:30

Exam II

CK

All chapters

All

L25,26

5/02

1:00 – 4:00

Integrated Immunology

 

HH/CK

All chapters

All

 

5/05

1:30 – 3:30

Exam III (State-Wide)

 

CK

All chapters

All


*Instructor keys:

CK: Dr. Chang Kim

HH: Dr. Harm HogenEsch

GK: Dr. Gina Kreisle
 
 

 



GRADING
 

    Exam I

25%
    Exam II  25%

      Statewide

35%

  Lecture Highlight

5%

Oral Presentation (Expert)

10%

          Total

100 points


Grade distribution:

IU Grades

Scores %

Purdue Grades

Scores %

H

90-100

A

90-100

HP

82-89.9

B

82-89.9

P

70-81.9

C

70-81.9

F

<70

F

<70



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