Lab Director:  
CKIM1
CKIM2
Chang H. Kim
Professor of Immunology
Section Head of Microbiology and Immunology
University Faculty Scholar

Department of Comparative Pathobiology, Purdue Veterinary Medicine

Weldon School of Biomedical Engineering
Purdue Cancer Center, Purdue University

E-Mail Address: chkim@purdue.edu
Phone:  765-494-0976, Fax:765-494-9830

Mailing Address:
VPTH RM 126, 725 Harrison St.
Purdue University, West Lafayette, IN 47907
Major Research Interests:  Cell trafficking and function in the hematolymphoid system
    Education and Trainings:

    B.S., Korea Advanced Institute of Science and Technology, Biology
    M.S., Korea Advanced Institute of Science and Technology, Biotechnology
    Research Scientist, LG Chem. LTD
    PhD, Indiana University School of Medicine, Immunology/Hematopoiesis
    Postdoctoral Fellow, Stanford University School of Medicine

    Awards and Honors:

    1998                     Rudell/Wright Scholarship, Walther Cancer Institute
    1998                     Presidential Award, Society for Leukocyte Biology
    1999-2002           Leukemia and Lymphoma Society Fellow
    2002-2005           Leukemia and Lymphoma Society Special Fellow
    2003                     New Investigator Award, Leukemia Research Foundation
    2005-2007           Sidney Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research
    2005                     Pfizer Showell Travel Award, American Association of Immunologists
    2006                     Pfizer Research Award of Excellence
    2007-2010           Crohn’s and Colitis Foundation Senior Investigator
    2008-2013           Purdue University Faculty Scholar
    2008, 2010          Seed for Success Award, Purdue University
    2010                     Entrepreneurial Leadership Academy Fellow
    2012                     PVM Research Award of Excellence, Purdue University


        Memberships and Service:

        1998-2002           Member, Society for Leukocyte Biology
        1999-2002           Member, International Society of Experimental Hematology
        2002-present       Member, American Association of Immunologists
        2002-2005           Council Member, Autumn Immunology Conference
        2004                     Workshop Chair, Chemokines, Autumn Immunology Conference
        2004                     Guest Editor for Current Medicinal Chemistry - Anti Inflammatory & Anti Allergy Agents,
        2005                     Workshop Chair, Regulatory T cells, Autumn Immunology Conference
        2005- present      Editorial Board Member. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
        2006                     Microbiology and Immunology Study Section, American Heart Association
        2007                     Microbiology and Immunology Study Section, American Heart Asscoiation
        2007                     Immunology and Virology Study Section, American Heart Association
        2007-present       Member, Society of Mucosal Immunology
        2007                     Phi Zeta Omicron Honor Society, Vice President
        2008                     Phi Zeta Omicron Honor Society, President
        2008                     Immunology and Virology Study Section, American Heart Association
        2008                     Transplantation Immunology Session Co-Chair and Panel Discussion Moderator
                                      The Sixth Annual Umbilical Cord Blood Transplantation Symposium, Los Angeles

        2008- present      Editorial Board Member.Journal of Blood Medicine
        2008- present      Editorial Board Member.The Open Autoimmunity Journal
        2008-2012           Member, American Socitey of Hematology
        2008                     NIH Special Emphasis Review Panel, National Heart, Lung and Blood Institute
        2009                     NIH NIAID Special Emphasis Review Panel, Immune Defense Mechanisms at the Mucosa. 
        2010                     NIH Program Project Special Emphasis Review Panel, National Heart, Lung and Blood Institute
        2010                     CDMRP Breast Cancer Research Program,Training-Cell Biology review panel
        2011                     National Medical Research Council (Ministry of Health, Singapore)
        2011                     NIH NIAID Immune Defense Mechanisms at the Mucosa Cooperative Study Group
        2011-present      
Editorial Board Member.Open Journal of Gastroenterology
        2011                     Program Reviewer, Japan Society for the Promotion of Science
        2011                     NIH NCRR, Shared Instrumentation review panel
        2011-present      
Editorial Board Member. World Journal of Immunology
        2011                     STOPENTERICS (EU) Round table 
        2012- present      Editorial Board Member. PLOS ONE
        2012                     NIH IHD (Immunity and Host Defense) Study Section
        2012                     Grant Reviewer, The Wellcome Trust India Alliance
        2012                     the Barts and The London Charity; Dutch Digestive Foundation ,
        2012                     National Medical Research Council (Ministry of Health, Singapore)
        2012                     NIH CMIB (Cell and Molecular Immunology B) Study Section
(& Feb and May 2014)
        2013                     Italian Ministry of Health Grant Program (2013)
        2013                     NIH NCRR Imaging/Microscopy Study Section,  ZRG1 CB-P
        2014                    
NIH Research in Biomedicine and Agriculture ZRG1 IDM-S

     


Research:

    Areas of research:

  • Mucosal immunology, inflammation and cancer
  • Migration of innate immune cells and lymphocytes
  • Development  of T cells (FoxP3+, Tr1, andTh17 cells)  and dendritic cells in health and disease
  • Roles of vitamin A  and retinoic acid in regulation of the immune system
  • Roles of gut microbes and metabolites (short chain fatty acids) in regulation of the immune system
  • Roles of hormones in regulation of the immune system
  • Regulation of Tfh, GC-T cells, and B cell antibody production
  • Trafficking and development of hematopoietic stem and progenitor cells

 




   Selected publications

Kim Lab publication citation impact (H index) in Google Scholar


  • Kim CH, Pelus LM, White JR, Appelbaum E, Johanson K, and Broxmeyer HE, CKb-11/MIP-3b/ELC is an efficacious chemoattractant for T- and B-cells. J. Immunol., 1998, 160:2418-2424.

  • Kim CH, Pelus LM, White JR, and Broxmeyer HE. Rapid communication: Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood, 1998, 91:4434-4443.

  • Kim CH, Pelus LM, White JR, and Broxmeyer HE. MIP-3b/ELC/CKb-11, a CC chemokine, is a chemoattractant for myeloid progenitor cells with a specificity for macrophage progenitors. J. Immunol., 1998, 161:2580-2585.

  • Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.

  • Youn BS, Kim CH, Smith F, Broxmeyer HE, TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. 1999, Blood. 94:2533-2536.

  • Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.

  • Braun SE, Chen SE, Foster RG, Kim CH, Hromas R, Broxmeyer, HE, Cornetta K, The CC chemokine CKb-11/MIP-3b/ELC/Exodus3 mediatesnbsp tumor rejection of murine breast cancer cells through natural killer cells. 2000, J. Immunol. 164:4025.

  • Andrew DP, Ruffing N, Kim CH (co-first authors), Miao A, Heath H, You-Li, Murphy K, Butcher EC, Wu L, CCR4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential. 2001, J. Immunol. 166:103.

  • Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.

  • Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.

  • Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.

  • Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.

  • Kim CH, Johnston Brent and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.

  • Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.

  • Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. J. Immunol. 2003, 170:421-429.

  • Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003, 111:1001-10.

  • Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. Differential chemokine responses and homing patterns of murine TCRalphabeta NKT cell subsets. J Immunol. 2003, 171:2960-9.

  • Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171(1):152-8.

  • Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.

  • Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.

  • Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.

  • Lim, HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183.

  • Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.

  • Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.

  • Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.

  • Kang SG, Piniecki RJ, Hogenesch H, Lim HW, Wiebke E, Braun SE, Matsumoto S, Kim CH.  Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology. 2007, 3: 966-81.

  • Lim HW, Kim CH. Loss of IL-7 Receptor alpha on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue. J Immunol. 2007, 179:7448-56.

  • Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007, 179(6):3724-33.

  • Lim HW, Lee J, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells.
    J Immunol. 2008 Jan 1;180(1):122-9.

  • Wang C, Kang SG, Lee J, Sun Z, Kim CH. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009 Mar;2(2):173-83  

  • Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.

  • Lee JH, Wang C, Kim CH. FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells. J Immunol. 2009 Nov 15;183(10):6377-86.
  • Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH, Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 Apr 26.
  • Wang C, Kang SG, Hogenesch H, Love PE, Kim CH. Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine. J Immunol. 2010, 184, 5519 -5526
  • Kang SG, Park J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-beta1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol. 2011, PMID: 20664575
  • Lee JH, Ulrich B, Cho J, Park J, Kim CH. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. PMID: 21768398
  • Wang C, Lee JH, Kim CH. Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. 2012. PLoS One. 2012;7(1):e30
  • Lee JH, Lydon JP, Kim CH. Generation of induced regulatory T cells with improved stability and suppressive activity with progesterone. Eur. J. Immunol. 2012 Jun 28. doi: 10.1002/eji.201142317
  • Chang J, Thangamani S, Kim MH, Ulrich B, Morris SM Jr, Kim CH. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur J Immunol. 2013 Apr;43(4):967-78. doi: 10.1002/eji.201242772.
  • Wang C, Thangamani S, Kim M, Gu BH, Lee JH, Taparowsky EJ, Kim CH. BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. J Exp Med. 2013 Mar 11;210(3):475-89. doi: 10.1084/jem.20121088.
  • Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice. Gastroenterology. 2013 May 7. doi:pii: S0016-5085(13)00708-7. 10.1053/j.gastro.2013.04.056.
  • Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, Walsh D, Olson MR, Kim MH, Tepper RS, Sun J, Kim CH, Taparowsky EJ, Zhou B, Kaplan MH.  Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest. 2013 Oct 8. pii: 69489. doi: 10.1172/JCI69489.
  • Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J, Kim CH. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 2014 Jun 11. doi: 10.1038/mi.2014.44

PUBMED Search for the recent publications



Book Chapters, Reviews and Commentaries:
  • Broxmeyer HE and Kim CH (1999) Chemokines and hematopoiesis. In Chemokines and Cancer. B. J. Rollins, Ed. Humana Press, NJ, pp. 263-291.

  • Kim CH and Broxmeyer HE. (2000) Chemokines for immature blood cells: effects on migration, proliferation and differentiation. In Chemokines and Allergic Diseases. M. E. Rothenberg, Ed. Marcel Dekker, New York, NY, pp. 227-261.

  • Broxmeyer HE, and Kim CH, Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. 1999, Exp. Hematol. 189:1987-92.

  • Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.

  • Kim CH, Campbell DJ, and Butcher EC, Nonpolarized memory T cells. 2001, Trends in Immunology. 22:527-530.

  • Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev. 2003, 195:58-71.

  • Kim CH, Butcher EC, Johnston B. Distinct subsets of human Va24-invariant NKT cells. 2002, Trends in Immunology, 23:516-9.

  • Kim CH. Chemokine-chemokine receptor network in immune cell trafficking. 2004, Current Drug Target- Immune, Endocrine & Metabolic Disorders. 2004:4, 343-361.

  • Kim CH and Johnson R. Trafficking potentials of unconventional T cell subsets. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents. 2004, 3:321-340.

  • Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.

  • Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In Chemokines, Chemokine Receptors, and Disease. Edited by Lisa Schwiebert. Current Topics in Membranes (Elsevier. 2005), 55:115-142.

  • Kim CH. Migration and function of Foxp3+ regulatory T cells in hematolymphoid system (review). Exp. Hematol. 2006, 34:1033-40.

  • Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868

  • Kim CH. Molecular targets of FoxP3+ regulatory T cells (Review). Mini Rev Med Chem. 2007, 7:1136-43.

  • Kim CH. Trafficking of FoxP3+ regulatory T cells: myths and facts. Arch Immunol Ther Exp (Review). 2007, 55:151-9.

  • Kim CH. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis (Chapter 8). In The Chemokine Receptors. Harrison and Lukacs. Ed. Humana Press, NJ, 2007, p119-138.

  • Kim CH. Roles of retinoic acid in induction of immunity and immune tolerance. Endocr Metab Immune Disord Drug Targets. 2008 Dec;8(4):289-94 (Review).

  • Kim CH. Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids. Clin Dev Immunol. 2008, 2008:416910 (Review).

  • Kim CH. Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. Immunol Cell Biol. 2009 Oct;87(7):502-4.

  • Kim CH. FOXP3 and its Role in the Immune System. In Forkhead Transcription Factors: Vital Elements in Biology and Medicine (Ed. Kenneth Maiese). Landes Bioscience. TX.  2009.
  • Kim CH. Migration and function of Th17 cells. Inflamm Allergy Drug Targets. 2009 Jul;8(3):221-8 (Review). 

  • Kim CH. Trafficking Receptors and Migration of Th17 Cell Subsets. In TH17 Cells in Health and Disease (Ed. Shuiping Jiang). 2010. Springer, New York.

  • Kim CH. The Gastrointestinal Immune System. Comprehensive Toxicology 2nd Edition. (Ed. Charlene McQueen). 2010. Oxford: Elsevier (Textbook Chapter). 

  • Kim CH. FOXP3 and its role in the immune system. Adv. Exp. Med. 665 17-29, 2010.

  • Kim CH. Retinoic acid, immunity, and inflammation. Vitam Horm. 2011;86:83-101.

  • Kim CH and Lee JH. Differentiation and trafficking potential of cord blood T helper cells. Ed HE Broxmeyer. In Cord Blood Biology, Transplantation, Banking and Regulation, 3rd Edition. AABB (American Association of Blood Banks). 2011
  • Kim CH. Host and microbial factors in regulation of T cells in the intestine. Frontiers in Immunology. 2013 Jun 10;4:141. doi: 10.3389/fimmu.2013.00141.
  • Kim CH. Crawling of effector T cells on extracellular matrix: role of integrins in interstitial migration in inflamed tissues. Cell Mol Immunol. 2014 Jan;11(1):1-4. doi: 10.1038/cmi.2013.47.
  • Kim MH and Kim CH. Short Chain Fatty Acids in Regulation of the Immune System and Tissue Inflammation in the Intestine. Ed. Cong-Jun Li. In Butyrate: Food Sources, Functions and Health Benefits. Nova Science Publishers. 2014




Postdoctoral Fellowship and Graduate Training Opportunities:

Qualifications for postdoctoral fellows:
• First author publications in reputable immunology or molecular biology journals (impact factor of 5 or greater)
• High productivity in research
• Recent PhD graduates
• High creativity, motivation (self-driven and active), and work ethic
• Functional levels of writtern and spoken English

Qualifications for graduate students:
• Significant levels of research experience with a record of publication is preferred
• High creativity, motivation (self-driven and active), and work ethic
• Good GRE and TOEFL scores (http://www.vet.purdue.edu/cpb/graduate-programs.php)
• Functional  levels of writtern and spoken English

Individuals with a record of productivity and relevant experience in cell and molecular biology and/or immunology are encouraged to apply.  Send curriculum vitae to Dr. Kim (chkim@purdue.edu).

 


  Last Revised: Jan 2014