Bartek's Home Page
Current position and expertise
Bartek Rajwa is an Associate Research Professor in the Bindley Bioscience Center at Purdue University where he is conducting studies on high-throughput cytometry, high-content imaging, biological image analysis, biological pattern recognition, and applications of statistical machine learning in cell biology, neuroscience and agriculture.
One of the most critical programmatic goals in life sciences is the integration of emerging “–omics” fields in order to define the biological functions of the genes encoded in each sequenced genome and to predict the impact of environment and external perturbations such as the presence of pharmaceuticals or toxins on the resultant phenotypes. An important part of this program has been contributed by data science tasked with merging the diverse “–omic” information inputs (such as genomics, proteomics, and metabolomics) with their phenotypic manifestations, and with the creation of predictive statistical models. Although historically informatics has played a significant role in delivering tools to mine genomic data, the extremely high dimensionality of phenotypic information requires new computational approaches. My expertise is in this emerging research field, attempting to integrate data from a variety of linked phenotype-oriented technologies ranging from flow cytometry through biological imaging to proteomics, lipidomics, and functional genomics. The unifying theme of my research is the effort to deconvolve the functionality of cellular systems via a quantitative mathematical description of their phenotypes. My studies employ applied mathematics, computer science, and machine learning to decipher and interpret complex phenotypic patterns observed using quantitative single-cell cell analysis. By addressing the issues of automated classification of phenotypes in the presence of incomplete and noisy information, my projects have a direct and profound impact of the fields of clinical cytometry (hematology, immunology, and oncology), high-content screening and drug discovery, toxicology, neuroscience, agriculture, biosecurity, and biosurveillance. Working with collaborators I developed new technologies for the biological data science including automated pipelines for clinical flow cytometry analysis, microorganism identification algorithms, and spectral information processing approaches for fluorescence and Raman cytometry and imaging. I am also a co-inventor of two breakthrough hardware technologies: multispectral flow cytometry (licensed by Sony Biotechnology, Inc.), and elastic light scatter microorganism identification system (licensed by Hettich GmbH und Co. K).
Page updated on 2020-05-22 19:53:23 -0400