Representative Publications

Zhen Hua, Zhe Li, Dawith Lim, Ali Ajrouch, Ahmad Karkash, Shadia Jalal, Michael Childress, John Turek, & David Nolte. Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies. Sci Rep 14, 2760 (2024).

Aaron A. Laviana, M.D., M.B.A., Elizabeth G. Schiftan, M.D., Joseph W. Mashni, M.D., Michael C. Large, M.D., Hristos Z. Kaimakliotis, M.D., David D. Nolte, Ph.D., John J. Turek, Ph.D., M.S., Ran An, Ph.D., Travis A. Morgan, M.B.A., Sam S. Chang, M.D., M.B.A. Biodynamic prediction of neoadjuvant chemotherapy response: Results from a prospective multicenter study of predictive accuracy among muscle-invasive bladder cancer patients Urol Oncol. 2023 Jun;41(6):295.e9-295.e17. doi: 10.1016/j.urolonc.2022.11.017. Epub 2022 Dec 13. PMID: 36522279

Kwan Jeong, Maria Josef Lopera, John J. Turek, David D. Nolte, "Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues," J. Biomed. Opt. 26(3), 030501 (2021), doi: 10.1117/1.JBO.26.3.030501.

Honggu Choi,  Zhe Li, Zhen Hua, Jessica Zuponcic, Eduardo Ximenes, John J. Turek, Michael R. Ladisch, & David D. Nolte. Doppler imaging detects bacterial infection of living tissue.  Nature Communications Biology, (2021) 4:178 | |

Honggu Choi, Zhe Li, Kwan Jeong, Jessica Zuponcic, Eduardo Ximenes, John Turek, Michael Ladisch, and David D. Nolte. Phase-sensitive intracellular Doppler fluctuation spectroscopy. Phys. Rev. Applied,
,, 2021.

Z. Li, I. Lorenzo-Lorenzo, R. An, J. Turek, D. Nolte, and Z. Machaty, "Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation," Appl. Opt. 60, A222-A233 (2021).

Jonathan Fine, Deepika Dhawan, Sagar Utturkar, Phillip San Miguel, Gaurav Chopra, John Turek, David Nolte, Michael O. Childress, Nadia A. Lanman. Integration of Biodynamic Imaging and RNA-seq predicts chemotherapy response in canine diffuse large B-cell lymphoma. bioRxiv 2020.09.11.290353; doi:

Blake A. Marcum, Zhe Li, John J. Turek, George E. Moore, David D. Nolte, Michael O. Childress. Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy‐induced neutropenia in cancer‐bearing dogs. Veterinary Medicine and Science. 2020.

Zhe Li,, Ran An, Wendy M. Swetzig, Margaux Kanis, Nkechiyere Nwani, John Turek, Daniela Matei, and David Nolte. Intracellular Optical Doppler Phenotypes of Chemosensitivity in Human Epithelial Ovarian Cancer. Sci. Reports, Preprint here -, 2020.

Zhe Li, Bihe Hu, Guang Li, Sharon E. Fox, Shadia I. Jalal, John Turek, J. Quincy Brown, David D. Nolte, Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue, J. Biomed. Opt. 25(9), 096006 (2020), doi: 10.1117/1.JBO.25.9.096006

Narayanan G, Merrill D, An R, Nolte DD, Turek JJ. Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein. Biochem Biophys Res Commun. 2019 May 15;. doi: 10.1016/j.bbrc.2019.05.072. [Epub ahead of print] PubMed PMID: 31103263.

Li Z, Sun H, Turek J, Jalal S, Childress M, Nolte DD. Doppler fluctuation spectroscopy of intracellular dynamics in living tissue. J Opt Soc Am A Opt Image Sci Vis. 2019 Apr 1;36(4):665-677. doi: 10.1364/JOSAA.36.000665. PubMed PMID: 31044988.

Choi H, Li Z, Sun H, Merrill D, Turek J, Childress M, Nolte D. Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma. Biomed Opt Express. 2018 May 1;9(5):2214-2228. doi: 10.1364/BOE.9.002214. eCollection 2018 May 1. PubMed PMID: 29760982; PubMed Central PMCID: PMC5946783.

Sun H, Merrill D, An R, Turek J, Matei D, Nolte DD. Biodynamic imaging for phenotypic profiling of three-dimensional tissue culture. J Biomed Opt. 2017 Jan 1;22(1):16007. doi: 10.1117/1.JBO.22.1.016007. PubMed PMID: 28301634; PubMed Central PMCID: PMC5221565.

Merrill D, An R, Sun H, Yakubov B, Matei D, Turek J, Nolte D. Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts. Sci Rep. 2016 Jan 6;6:18821. doi: 10.1038/srep18821. PubMed PMID: 26732545; PubMed Central PMCID: PMC4702146.

Custead MR, An R, Turek JJ, Moore GE, Nolte DD, Childress MO. Predictive value of ex vivo biodynamic imaging in determining response to chemotherapy in dogs with spontaneous non-Hodgkin's lymphomas: a preliminary study. Conv. Science Physical Oncology. 2015;1(1). pii: 015003. doi: 10.1088/2057-1739/1/1/015003. Epub 2015 Oct 6: PMID:27280042.

Nolte, D., Turek, J. An, R. Biodynamic imaging for artificial reproductive technology. Mol. Reprod.Dev. 82 (7,8), 500, 2015.

Merrill D, An R, Turek J, Nolte DD. Digital holography of intracellular dynamics to probe tissue physiology. Appl Opt. 2015 Jan 1;54(1):A89-97. doi: 10.1364/AO.54.000A89. PubMed PMID: 25967027; PubMed Central PMCID: PMC4668827.

An R, Wang C, Turek J, Machaty Z, Nolte DD. Biodynamic imaging of live porcine oocytes, zygotes and blastocysts for viability assessment in assisted reproductive technologies. Biomed Opt Express. 2015 Mar 1;6(3):963-76. doi: 10.1364/BOE.6.000963. eCollection 2015 Mar 1. PubMed PMID: 25798318; PubMed Central PMCID: PMC4361448.

Condello S, Morgan CA, Nagdas S, Cao L, Turek J, Hurley TD, Matei D. ß-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene. 2015 Apr 30;34(18):2297-308. doi: 10.1038/onc.2014.178. Epub 2014 Jun 23. PubMed PMID: 24954508; PubMed Central PMCID: PMC4275429.

An R, Merrill D, Avramova L, Sturgis J, Tsiper M, Robinson JP, Turek J, Nolte DD. Phenotypic profiling of Raf inhibitors and mitochondrial toxicity in 3D tissue using biodynamic imaging. J Biomol Screen. 2014 Apr;19(4):526-37. doi: 10.1177/1087057113516674. Epub 2013 Dec 20. PubMed PMID: 24361645; PubMed Central PMCID: PMC4028716.

An R, Turek J, Matei DE, Nolte D. Live tissue viability and chemosensitivity assays using digital holographic motility contrast imaging. Appl Opt. 2013 Jan 1;52(1):A300-9. doi: 10.1364/AO.52.00A300. PubMed PMID: 23292406.

Turek J, Ebetino FH, Lundy MW, Sun S, Kashemirov BA, McKenna CE, Gallant MA, Plotkin LI, Bellido T, Duan X, Triffitt JT, Russell RG, Burr DB, Allen MR. Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits. Calcif Tissue Int. 2012 Mar;90(3):202-10. doi: 10.1007/s00223-012-9570-0. Epub 2012 Jan 17. PubMed PMID: 22249525.

Nolte DD, An R, Turek J, Jeong K. Tissue dynamics spectroscopy for phenotypic profiling of drug effects in three-dimensional culture. Biomed Opt Express. 2012 Nov 1;3(11):2825-41. doi: 10.1364/BOE.3.002825. Epub 2012 Oct 15. PubMed PMID: 23162721; PubMed Central PMCID: PMC3493238.

 Nolte DD, An R, Turek J, Jeong K. Tissue dynamics spectroscopy for three-dimensional tissue-based drug screening. J Lab Autom. 2011 Dec;16(6):431-42. PMID: 22093300.

Nolte DD, An R, Turek J, Jeong K. Holographic tissue dynamics spectroscopy. J Biomed Opt. 2011 Aug;16(8):087004. doi: 10.1117/1.3615970. PubMed PMID: 21895331.

Allen MR, Turek JJ, Phipps RJ, Burr DB. Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate. Bone. 2011 Jul;49(1):128-32. doi: 10.1016/j.bone.2010.07.011. Epub 2010 Jul 15. PubMed PMID: 20637914.

Jeong K, Turek JJ, Nolte DD. Speckle fluctuation spectroscopy of intracellular motion in living tissue using coherence-domain digital holography. J Biomed Opt. 2010 May-Jun;15(3):030514. doi: 10.1117/1.3456369. PubMed PMID: 20614997.

Salvador M, Prauzner J, Köber S, Meerholz K, Turek JJ, Jeong K, Nolte DD. Three-dimensional holographic imaging of living tissue using a highly sensitive photorefractive polymer device. Opt Express. 2009 Jul 6;17(14):11834-49. doi: 10.1364/oe.17.011834. PubMed PMID: 19582098.

K. Jeong, J. J. Turek, M. R. Melloch, and D. D. Nolte, Multiple-scattering speckle in holographic optical coherence imaging. Applied Physics B-Lasers And Optics, vol. 95, pp. 617-625, 2009.

Jeong, K., John J. Turek, Michael R. Melloch, David D. Nolte, Functional Imaging in Photorefractive Tissue Speckle Holography, Optics Communications. 7:1860-1869. 2008.

Jeong K, Turek JJ, Nolte DD. Volumetric motility-contrast imaging of tissue response to cytoskeletal anti-cancer drugs. Opt Express. 2007 Oct 17;15(21):14057-64. doi: 10.1364/oe.15.014057. PubMed PMID: 19550678.

Jeong K, Turek JJ, Nolte DD. Fourier-domain digital holographic optical coherence imaging of living tissue. Appl Opt. 2007 Aug 1;46(22):4999-5008. PubMed PMID: 17676107.

Jeong K, Peng L, Turek JJ, Melloch MR, Nolte DD. Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye. Appl Opt. 2005 Apr 1;44(10):1798-805. PubMed PMID: 15813515.

 Turek, J.J. Fat and Wound Healing.  In Nutrition and Wound Healing. Joseph A. Molnar, ed. CRC Press, Boca Raton, FL. Pages 27-47, 2007. 

Jia Y, Turek JJ. Inducible nitric oxide synthase links NF-kappaB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing. Lipids Health Dis. 2005 Jul 12;4:14. doi: 10.1186/1476-511X-4-14. PubMed PMID: 16011805; PubMed Central PMCID: PMC1185561.

Jia Y, Turek JJ. Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids. J Nutr Biochem. 2005 Aug;16(8):500-6. doi: 10.1016/j.jnutbio.2005.01.016. PubMed PMID: 16043032.

 Yu P, Mustata M, Peng L, Turek JJ, Melloch MR, French PM, Nolte DD. Holographic optical coherence imaging of rat osteogenic sarcoma tumor spheroids. Appl Opt. 2004 Sep 1;43(25):4862-73. PubMed PMID: 15449473.

Jia Y, Turek JJ. Polyenoic fatty acid ratios alter fibroblast collagen production via PGE2 and PGE receptor subtype response. Exp Biol Med (Maywood). 2004 Jul;229(7):676-83. PubMed PMID: 15229362.

Yu P, Peng L, Mustata M, Turek JJ, Melloch MR, Nolte DD. Time-dependent speckle in holographic optical coherence imaging and the health of tumor tissue. Opt Lett. 2004 Jan 1;29(1):68-70. PubMed PMID: 14719663.

Yu, P., M. Mustata, J.J. Turek,  P.M.W. French, M.R. Melloch, D.D. Nolte. Holographic optical coherence imaging of tumor spheroids. Appl. Physics Letters, Vol. 83, No. 3, pp. 575–577, 21 July 2003.

Turek JJ, Watkins BA, Schoenlein IA, Allen KG, Hayek MG, Aldrich CG. Oxidized lipid depresses canine growth, immune function, and bone formation. J Nutr Biochem. 2003 Jan;14(1):24-31. PubMed PMID: 12559474.

Leskovar A, Turek J, Borgens RB. Giant multinucleated macrophages occur in acute spinal cord injury. Cell Tissue Res. 2001 May;304(2):311-5. PubMed PMID: 11396724.

Turek J. Image processing and 2-D morphometry. Curr Protoc Cytom. 2001 May;Chapter 10:Unit 10.11. doi: 10.1002/0471142956.cy1011s13. PubMed PMID: 18770675.

Guptill L, Wu CC, Glickman L, Turek J, Slater L, HogenEsch H. Extracellular Bartonella henselae and artifactual intraerythrocytic pseudoinclusions in experimentally infected cats. Vet Microbiol. 2000 Oct 1;76(3):283-90. PubMed PMID: 10973702.

Gunasekar PG, Borowitz JL, Turek JJ, Van Horn DA, Isom GE. Endogenous generation of cyanide in neuronal tissue: involvement of a peroxidase system. J Neurosci Res. 2000 Sep 1;61(5):570-5. doi: 10.1002/1097-4547(20000901)61:5<570::AID-JNR12>3.0.CO;2-V. PubMed PMID: 10956427.

Leskovar A, Moriarty LJ, Turek JJ, Schoenlein IA, Borgens RB. The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J Exp Biol. 2000 Jun;203(Pt 12):1783-95. PubMed PMID: 10821736.

Suckow, M.A., K. Park, L. Siger, J. Turek, D. Van Horn, D. Taylor, H. Park, T.L. Bowersock. Immunogenicity of antigens in boiled alginate microspheres. J. Biomaterials Sci (Polymer Edition) 11:55-68, 2000.

Asem EK, Stingley-Salazar SR, Robinson JP, Turek JJ. Effect of basal lamina on progesterone production by chicken granulosa cells in vitro--influence of follicular development. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Feb;125(2):233-44. PubMed PMID: 11790345.

Asem EK, Feng S, Stingley-Salazar SR, Turek JJ, Peter AT, Robinson JP. Basal lamina of avian ovarian follicle: influence on morphology of granulosa cells in-vitro. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Feb;125(2):189-201. PubMed PMID: 11790341.

Asem EK, Stingley-Salazar SR, Robinson JP, Turek JJ. Identification of some components of basal lamina of avian ovarian follicle. Poult Sci. 2000 Apr;79(4):589-601. doi: 10.1093/ps/79.4.589. PubMed PMID: 10780659.

Hankenson KD, Watkins BA, Schoenlein IA, Allen KG, Turek JJ. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proc Soc Exp Biol Med. 2000 Jan;223(1):88-95. PubMed PMID: 10632966.

Elkin RG, Yan Z, Zhong Y, Donkin SS, Buhman KK, Story JA, Turek JJ, Porter RE Jr, Anderson M, Homan R, Newton RS. Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition. J Nutr. 1999 May;129(5):1010-9. doi: 10.1093/jn/129.5.1010. PubMed PMID: 10222393.

Kearns RJ, Hayek MG, Turek JJ, Meydani M, Burr JR, Greene RJ, Marshall CA, Adams SM, Borgert RC, Reinhart GA. Effect of age, breed and dietary omega-6 (n-6): omega-3 (n-3) fatty acid ratio on immune function, eicosanoid production, and lipid peroxidation in young and aged dogs. Vet Immunol Immunopathol. 1999 Aug 2;69(2-4):165-83. PubMed PMID: 10507303.

Fan MZ, Adeola O, Turek JJ, Asem EK. Methodological aspects of measuring amino acid uptake in studies with porcine jejunal brush border membrane vesicles. Physiol Res. 1999;48(4):281-9. PubMed PMID: 10638679.

Suckow M.A., L Siger, TL Bowersock, J.J. Turek, D Van Horn, D Borie, A Taylor, H Park, K Park. Alginate microparticles for vaccine delivery. In: Polysaccharide Applications: Cosmetics and Pharmaceuticals. Symposium Series 737, American Chemical Society. (M El-Nokaly and H Soini, Eds.) Washington, DC. 1999.

Robinson, J.P. and J.J. Turek. Microscope image processing and analysis. Encyclopedia of Electronics and Engineering. Wiley-Liss, New York. Volume 13: 9-21. 1999.

Hankenson KD, Turek JJ. Porcine anterior cruciate ligament fibroblasts are similar to cells derived from the ligamentum teres, another non-healing intra-articular ligament. Connect Tissue Res. 1999;40(1):13-21. PubMed PMID: 10770647.

Turek, J.J., Y. Li, I.A Schoenlein, K.G.D. Allen, and B.A. Watkins. Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary (n-6):(n-3) fatty acid ratio. J. Nutr. Biochem. 9:258-266. 1998.

Mathias CJ, Wang S, Waters DJ, Turek JJ, Low PS, Green MA. Indium-111-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical. J Nucl Med. 1998 Sep;39(9):1579-85. PubMed PMID: 9744347.

Thiagarajan D, Saeed M, Turek J, Asem E. In vitro attachment and invasion of chicken ovarian granulosa cells by Salmonella enteritidis phage type 8. Infect Immun. 1996 Dec;64(12):5015-21. PubMed PMID: 8945540; PubMed Central PMCID: PMC174482.

Woodyard, L.L., T.L. Bowersock, J.J. Turek, G.P. McCabe, J. DeFord. A comparison of the effects of several silver-treated intravenous catheters on the survival of Staphylococci in the suspension and their adhesion to the catheter surface. J. of Controlled Release. 1996.

Watkins BA, Xu H, Turek JJ. Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. Proc Soc Exp Biol Med. 1996 Jun;212(2):153-9. PubMed PMID: 8650253.

Turek, J.J., I.A. Schoenlein, B.A. Watkins, W.G. Van Alstine, L.K. Clark and K. Knox. Dietary polyunsaturated fatty acids modulate porcine response to Mycoplasma hyopneumoniae infection. J. Nutrition. 126: 1541-1548.1996

Schinkel, A.P., L.K. Clark, G. Stevenson, K.E. Knox, J. Nielsen, A.L. Grant, D.L. Hancock, J. Turek. Effects of antigenic challenge on growth and composition of segregated early weaned pigs. Swine Health and Production, 3:228-234.1995

Knapp DW, Turek JJ, DeNicola DB, Chan TC, Carter WO, Snyder PW, Robinson JP. Ultrastructure and cytochemical staining characteristics of canine natural killer cells. Anat Rec. 1995 Dec;243(4):509-15. doi: 10.1002/ar.1092430413. PubMed PMID: 8597297.

Turek, J.J., and J.P. Robinson. Leucine aminopeptidase activity by flow cytometry. Methods in Cell Biology. Vol. 41, Chapter 30, pp. 461-467. Academic Press. 1994.

Reagan,W.J., C. Carter, J.J. Turek. Eccentrocytosis in equine red maple leaf toxicosis. Vet.Clin. Path. 23: 123-127, 1994.

Turek, J.J., I.A. Schoenlein, L.K. Clark, and W.G. Van Alstine. Dietary polyunsaturated fatty acid effects on immune cells of the porcine lung. J. Leuk. Biol. 56: 599-604, 1994.

Guo P, Scholz E, Turek J, Nodgreen R, Maloney B. Assembly pathway of avian infectious laryngotracheitis virus. Am J Vet Res. 1993 Dec;54(12):2031-9. PubMed PMID: 8116934.

Turek JJ, Leamon CP, Low PS. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci. 1993 Sep;106 ( Pt 1):423-30. PubMed PMID: 8270640.

Turek JJ, Schoenlein IA. Indomethacin-induced gastrointestinal ulcers in rats: effects of dietary fatty acids and endotoxin. Prostaglandins Leukot Essent Fatty Acids. 1993 Mar;48(3):229-32. PubMed PMID: 8469682.

Knapp DW, Leibnitz RR, DeNicola DB, Turek JJ, Teclaw R, Shaffer L, Chan TC. Measurement of NK activity in effector cells purified from canine peripheral lymphocytes. Vet Immunol Immunopathol. 1993 Jan;35(3-4):239-51. PubMed PMID: 8430495.

Burkhardt JE, Hill MA, Turek JJ, Carlton WW. Ultrastructural changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol. 1992 May;29(3):230-8. doi: 10.1177/030098589202900307. PubMed PMID: 1621334.

Long GG, Turek J, Diekman MA, Scheidt AB. Effect of zearalenone on days 7 to 10 post-mating on blastocyst development and endometrial morphology in sows. Vet Pathol. 1992 Jan;29(1):60-7. doi: 10.1177/030098589202900108. PubMed PMID: 1532680.

Wolf DC, Turek JJ, Carlton WW. Early sequential ultrastructural renal alterations induced by 2-bromoethylamine hydrobromide in the Swiss ICR mouse. Vet Pathol. 1992 Nov;29(6):528-35. doi: 10.1177/030098589202900607. PubMed PMID: 1448899.

Turek JJ, Schoenlein IA, Bottoms GD. The effect of dietary n-3 and n-6 fatty acids on tumor necrosis factor-alpha production and leucine aminopeptidase levels in rat peritoneal macrophages. Prostaglandins Leukot Essent Fatty Acids. 1991 Jul;43(3):141-9. PubMed PMID: 1871180.

Babbs CF, Cregor MD, Turek JJ, Badylak SF. Endothelial superoxide production in buffer perfused rat lungs, demonstrated by a new histochemical technique. Lab Invest. 1991 Oct;65(4):484-96. PubMed PMID: 1656143.

Babbs CF, Salaris SC, Turek JJ. Cytochemical studies of hydrogen peroxide generation in postischemic hepatocytes. Am J Physiol. 1991 Jan;260(1 Pt 2):H123-9. doi: 10.1152/ajpheart.1991.260.1.H123. PubMed PMID: 1992789.

Babbs CF, Cregor MD, Turek JJ, Badylak SF. Endothelial superoxide production in the isolated rat heart during early reperfusion after ischemia. A histochemical study. Am J Pathol. 1991 Nov;139(5):1069-80. PubMed PMID: 1659203; PubMed Central PMCID: PMC1886333.

Maduh EU, Turek JJ, Borowitz JL, Rebar A, Isom GE. Cyanide-induced neurotoxicity: calcium mediation of morphological changes in neuronal cells. Toxicol Appl Pharmacol. 1990 Apr;103(2):214-21. PubMed PMID: 2330585.

Jaeger LA, Lamar CH, Turek JJ. Lectin binding to small intestinal goblet cells of newborn, suckling, and weaned pigs. Am J Vet Res. 1989 Nov;50(11):1984-7. PubMed PMID: 2619128.



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