The Zhou Laboratory

  • Publications

Complete List of Published Work:
Journal Articles

  1. Zhang Y, Kao DS, Gu B, Bomjan R, Srivastava M, Lu H, Zhou D, Tao WA. Tracking Pathogen Infections by Time-Resolved Chemical Proteomics. Angew Chem Int Ed Engl. 2019 Nov 26;. doi: 10.1002/anie.201911078. [Epub ahead of print] PubMed PMID: 31769915.
  2. Bomjan R, Zhang M, Zhou D. YshB Promotes Intracellular Replication and Is Required for Salmonella Virulence. J Bacteriol. 2019 Sep 1;201(17). doi: 10.1128/JB.00314-19. Print 2019 Sep 1. PubMed PMID: 31182500; PubMed Central PMCID: PMC6689311.
  3. Bourgeois JS, Zhou D, Thurston TLM, Gilchrist JJ, Ko DC. Methylthioadenosine Suppresses Salmonella Virulence. Infect Immun. 2018 Sep;86(9). doi: 10.1128/IAI.00429-18. Print 2018 Sep. PubMed PMID: 29866910; PubMed Central PMCID: PMC6105896.
  4. Yin Y, Zhou D. Organoid and Enteroid Modeling of Salmonella Infection. Front Cell Infect Microbiol. 2018;8:102. doi: 10.3389/fcimb.2018.00102. eCollection 2018. Review. PubMed PMID: 29670862; PubMed Central PMCID: PMC5894114.
  5. Cheng S, Wang L, Liu Q, Qi L, Yu K, Wang Z, Wu M, Liu Y, Fu J, Hu M, Li M, Zhou D, Liu X. Identification of a Novel Salmonella Type III Effector by Quantitative Secretome Profiling. Mol Cell Proteomics. 2017 Dec;16(12):2219-2228. doi: 10.1074/mcp.RA117.000230. Epub 2017 Sep 8. PubMed PMID: 28887382; PubMed Central PMCID: PMC5724182.
  6. Wang L, Cai X, Wu S, Bomjan R, Nakayasu ES, Händler K, Hinton JCD, Zhou D. InvS Coordinates Expression of PrgH and FimZ and Is Required for Invasion of Epithelial Cells by Salmonella enterica serovar Typhimurium. J Bacteriol. 2017 Jul 1;199(13). doi: 10.1128/JB.00824-16. Print 2017 Jul 1. PubMed PMID: 28439039; PubMed Central PMCID: PMC5472816.
  7. Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, Wen Y, Zhou D, Freeman J, Kuang S. Stage-specific effects of Notch activation during skeletal myogenesis. Elife. 2016 Sep 19;5. doi: 10.7554/eLife.17355. PubMed PMID: 27644105; PubMed Central PMCID: PMC5070950.
  8. Piscatelli HL, Li M, Zhou D. Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry. Cell Microbiol. 2016 May;18(5):705-19. doi: 10.1111/cmi.12542. Epub 2015 Dec 9. PubMed PMID: 26537021.
  9. Zhao EY, Bao HX, Tang L, Zou QH, Liu WQ, Zhu DL, Chin J, Dong YY, Li YG, Cao FL, Poppe C, Sanderson KE, Johnston RN, Zhou D, Liu GR, Liu SL. Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains. Mol Genet Genomics. 2013 Nov;288(11):549-57. doi: 10.1007/s00438-013-0762-8. Epub 2013 Aug 11. PubMed PMID: 23933962.
  10. Perrett CA, Zhou D. Salmonella type III effector SopB modulates host cell exocytosis. Emerg Microbes Infect. 2013 May;2(5):e32. doi: 10.1038/emi.2013.31. Epub 2013 May 22. PubMed PMID: 26038467; PubMed Central PMCID: PMC3675406.
  11. Li D, Wang X, Wang L, Zhou D. The actin-polymerizing activity of SipA is not essential for Salmonella enterica serovar Typhimurium-induced mucosal inflammation. Infect Immun. 2013 May;81(5):1541-9. doi: 10.1128/IAI.00337-12. Epub 2013 Feb 25. PubMed PMID: 23439302; PubMed Central PMCID: PMC3648018.
  12. Myeni SK, Wang L, Zhou D. SipB-SipC complex is essential for translocon formation. PLoS One. 2013;8(3):e60499. doi: 10.1371/journal.pone.0060499. Epub 2013 Mar 27. PubMed PMID: 23544147; PubMed Central PMCID: PMC3609803.
  13. Perrett CA, Lin DY, Zhou D. Interactions of bacterial proteins with host eukaryotic ubiquitin pathways. Front Microbiol. 2011;2:143. doi: 10.3389/fmicb.2011.00143. eCollection 2011. PubMed PMID: 21772834; PubMed Central PMCID: PMC3131157.
  14. Piscatelli H, Kotkar SA, McBee ME, Muthupalani S, Schauer DB, Mandrell RE, Leong JM, Zhou D. The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS One. 2011 Apr 26;6(4):e19331. doi: 10.1371/journal.pone.0019331. PubMed PMID: 21541301; PubMed Central PMCID: PMC3082576.
  15. Perrett CA, Zhou D. Type three secretion system effector translocation: one step or two?. Front Microbiol. 2011;2:50. doi: 10.3389/fmicb.2011.00050. eCollection 2011. PubMed PMID: 21833307; PubMed Central PMCID: PMC3153026.
  16. Lin DY, Diao J, Zhou D, Chen J. Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7. J Biol Chem. 2011 Jan 7;286(1):441-9. doi: 10.1074/jbc.M110.167643. Epub 2010 Oct 27. PubMed PMID: 20980253; PubMed Central PMCID: PMC3013003.
  17. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15;330(6002):390-393. doi: 10.1126/science.1194598. PubMed PMID: 20947770; PubMed Central PMCID: PMC4085780.
  18. Wang X, Li D, Qu D, Zhou D. Involvement of TIP60 acetyltransferase in intracellular Salmonella replication. BMC Microbiol. 2010 Aug 26;10:228. doi: 10.1186/1471-2180-10-228. PubMed PMID: 20796290; PubMed Central PMCID: PMC3313078.
  19. Myeni SK, Zhou D. The C terminus of SipC binds and bundles F-actin to promote Salmonella invasion. J Biol Chem. 2010 Apr 30;285(18):13357-63. doi: 10.1074/jbc.M109.094045. Epub 2010 Mar 8. PubMed PMID: 20212042; PubMed Central PMCID: PMC2859494.
  20. Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat Struct Mol Biol. 2008 Jan;15(1):65-70. doi: 10.1038/nsmb1346. Epub 2007 Dec 9. PubMed PMID: 18066077.
  21. Chang J, Myeni SK, Lin TL, Wu CC, Staiger CJ, Zhou D. SipC multimerization promotes actin nucleation and contributes to Salmonella-induced inflammation. Mol Microbiol. 2007 Dec;66(6):1548-56. doi: 10.1111/j.1365-2958.2007.06024.x. Epub 2007 Nov 12. PubMed PMID: 18005098.
  22. Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic. 2007 Oct;8(10):1365-74. doi: 10.1111/j.1600-0854.2007.00613.x. Epub 2007 Jul 20. PubMed PMID: 17645435.
  23. Zuo X, Zhang J, Zhang Y, Hsu SC, Zhou D, Guo W. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat Cell Biol. 2006 Dec;8(12):1383-8. doi: 10.1038/ncb1505. Epub 2006 Nov 5. PubMed PMID: 17086175.
  24. Zhang Y, Higashide WM, McCormick BA, Chen J, Zhou D. The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase. Mol Microbiol. 2006 Nov;62(3):786-93. doi: 10.1111/j.1365-2958.2006.05407.x. PubMed PMID: 17076670.
  25. Hu H, Sa Q, Koehler TM, Aronson AI, Zhou D. Inactivation of Bacillus anthracis spores in murine primary macrophages. Cell Microbiol. 2006 Oct;8(10):1634-42. doi: 10.1111/j.1462-5822.2006.00738.x. PubMed PMID: 16984418.
  26. Higashide W, Zhou D. The first 45 amino acids of SopA are necessary for InvB binding and SPI-1 secretion. J Bacteriol. 2006 Apr;188(7):2411-20. doi: 10.1128/JB.188.7.2411-2420.2006. PubMed PMID: 16547027; PubMed Central PMCID: PMC1428425.
  27. Zhang Y, Higashide W, Dai S, Sherman DM, Zhou D. Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. J Biol Chem. 2005 Nov 18;280(46):38682-8. doi: 10.1074/jbc.M506309200. Epub 2005 Sep 20. PubMed PMID: 16176924.
  28. Chang J, Chen J, Zhou D. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Mol Microbiol. 2005 Mar;55(5):1379-89. doi: 10.1111/j.1365-2958.2004.04480.x. PubMed PMID: 15720547.
  29. Dai S, Zhou D. Secretion and function of Salmonella SPI-2 effector SseF require its chaperone, SscB. J Bacteriol. 2004 Aug;186(15):5078-86. doi: 10.1128/JB.186.15.5078-5086.2004. PubMed PMID: 15262944; PubMed Central PMCID: PMC451637.
  30. Dai S, Sarmiere PD, Wiggan O, Bamburg JR, Zhou D. Efficient Salmonella entry requires activity cycles of host ADF and cofilin. Cell Microbiol. 2004 May;6(5):459-71. doi: 10.1111/j.1462-5822.2004.00375.x. PubMed PMID: 15056216.
  31. Galkin VE, Orlova A, VanLoock MS, Zhou D, Galán JE, Egelman EH. The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin. Nat Struct Biol. 2002 Jul;9(7):518-21. doi: 10.1038/nsb811. PubMed PMID: 12055622.
  32. Higashide W, Dai S, Hombs VP, Zhou D. Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells. Cell Microbiol. 2002 Jun;4(6):357-65. doi: 10.1046/j.1462-5822.2002.00196.x. PubMed PMID: 12116966.
  33. Zhou D. Collective efforts to modulate the host actin cytoskeleton by Salmonella type III-secreted effector proteins. Trends Microbiol. 2001 Dec;9(12):567-9; discussion 569-70. doi: 10.1016/s0966-842x(01)02227-2. PubMed PMID: 11728859.
  34. Zhou D, Galán J. Salmonella entry into host cells: the work in concert of type III secreted effector proteins. Microbes Infect. 2001 Nov-Dec;3(14-15):1293-8. doi: 10.1016/s1286-4579(01)01489-7. Review. PubMed PMID: 11755417.
  35. Zhou D, Chen LM, Hernandez L, Shears SB, Galán JE. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol Microbiol. 2001 Jan;39(2):248-59. doi: 10.1046/j.1365-2958.2001.02230.x. PubMed PMID: 11136447.
  36. Mitra K, Zhou D, Galán JE. Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica. FEBS Lett. 2000 Sep 29;482(1-2):81-4. doi: 10.1016/s0014-5793(00)02040-8. PubMed PMID: 11018527.
  37. Galan JE, Zhou D. Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8754-61. doi: 10.1073/pnas.97.16.8754. PubMed PMID: 10922031; PubMed Central PMCID: PMC34008.
  38. Zhou D, Mooseker MS, Galán JE. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10176-81. doi: 10.1073/pnas.96.18.10176. PubMed PMID: 10468582; PubMed Central PMCID: PMC17862.
  39. Zhou D, Hardt WD, Galán JE. Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island. Infect Immun. 1999 Apr;67(4):1974-81. PubMed PMID: 10085045; PubMed Central PMCID: PMC96555.
  40. Zhou D, Mooseker MS, Galán JE. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science. 1999 Mar 26;283(5410):2092-5. doi: 10.1126/science.283.5410.2092. PubMed PMID: 10092234.
  41. Estabrook MM, Zhou D, Apicella MA. Nonopsonic phagocytosis of group C Neisseria meningitidis by human neutrophils. Infect Immun. 1998 Mar;66(3):1028-36. PubMed PMID: 9488392; PubMed Central PMCID: PMC108012.
  42. Zhou D, Apicella MA. Plasmids with erythromycin resistance and catechol 2,3-dioxygenase- or beta-galactosidase-encoding gene cassettes for use in Neisseria spp. Gene. 1996 May 24;171(1):133-4. doi: 10.1016/0378-1119(96)00103-5. PubMed PMID: 8675023.
  43. Apicella MA, Ketterer M, Lee FK, Zhou D, Rice PA, Blake MS. The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae. J Infect Dis. 1996 Mar;173(3):636-46. doi: 10.1093/infdis/173.3.636. PubMed PMID: 8627027.
  44. Lee FK, Stephens DS, Gibson BW, Engstrom JJ, Zhou D, Apicella MA. Microheterogeneity of Neisseria lipooligosaccharide: analysis of a UDP-glucose 4-epimerase mutant of Neisseria meningitidis NMB. Infect Immun. 1995 Jul;63(7):2508-15. PubMed PMID: 7790063; PubMed Central PMCID: PMC173335.
  45. Zhou D, Lee NG, Apicella MA. Lipooligosaccharide biosynthesis in Neisseria gonorrhoeae: cloning, identification and characterization of the alpha 1,5 heptosyltransferase I gene (rfaC). Mol Microbiol. 1994 Nov;14(4):609-18. doi: 10.1111/j.1365-2958.1994.tb01300.x. PubMed PMID: 7891550.
  46. Stephens DS, McAllister CF, Zhou D, Lee FK, Apicella MA. Tn916-generated, lipooligosaccharide mutants of Neisseria meningitidis and Neisseria gonorrhoeae. Infect Immun. 1994 Jul;62(7):2947-52. PubMed PMID: 7516313; PubMed Central PMCID: PMC302902.
  47. Zhou D, Stephens DS, Gibson BW, Engstrom JJ, McAllister CF, Lee FK, Apicella MA. Lipooligosaccharide biosynthesis in pathogenic Neisseria. Cloning, identification, and characterization of the phosphoglucomutase gene. J Biol Chem. 1994 Apr 15;269(15):11162-9. PubMed PMID: 8157643.
  48. Kim JJ, Zhou D, Mandrell RE, Griffiss JM. Effect of exogenous sialylation of the lipooligosaccharide of Neisseria gonorrhoeae on opsonophagocytosis. Infect Immun. 1992 Oct;60(10):4439-42. PubMed PMID: 1398958; PubMed Central PMCID: PMC257487.

Book Chapters

  1. Zhou D. Bacterial invasion into non-phagocytic cells . In: Molecular Paradigms of Infectious Disease. Nickerson CA, Schurr MJ, editors. Business Media: Springer Science; 2004. p.247-273.