Advanced Protein Structure-Function

9

2

Advanced enzyme catalysis, kinetics, inhibition, regulation, and applications

10

4

Cytochrome P450 and Nitric Oxidases

11

1

Exam I

1

Nucleic Acid Structure: Stability, pitch, deformation, supercoiling, topoisomerases, compaction, melting/annealing, helicases

2

2

Protein-DNA interactions: Transcription Regulatory Factors

8.8-8.9

1

Membrane transporters

12.6-12.11

1

Signal transduction

13

2

DNA replication: Initial melting, regulation, drugs, genes

4

1

Exam II

1

Transcription and post transcription: Initial melting and regulation by DNA binding proteins in eukaryotes, DNA structure, and novel mechanism; alternative splicing; RNA interference

5 and 8

2

Translation: Ribosome structure, function, and translation inhibitors

Post-translation: Protein targeting, modification, and targeted degradation

6

0.5

Advanced biotechnology

7

1

Clinically relevant aspects of carbohydrate metabolism and bioenergetics

14,15,16

0.5

Advanced Lipid metabolism I: FA and TG absorption, distribution, and regulation of metabolisms and diseases

17

2

Advanced Lipid metabolism II: Cholesterol transport, metabolism, and excretion

18

1

Advanced Amino Acid metabolism: One carbon metabolism, relation to certain vitamin deficiencies, basic clinical elements (N balance, essential AAs, diseases, creatine and creatinine)

19.1 – 19.6

2

Heme metabolism and iron

19.7 – 19.8 and 26.10

1

Nucleotide metabolism

20

1

Metabolic Interrelationships and hormonal regulation; macro-nutrition; obesity and diabetes

21 and 27

2

Exam 3 (during final exam week)

1