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I. Reviews Summarizing Zheng Lab’s Research

O’Neal S and Zheng W* (2015). Manganese toxicity upon overexposure: A decade in review.Current Environmental Health Reports2:315-328.

Zheng W* and Monnot AD (2012).Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases.Pharmacol Ther 133:177-188. (PMCID: PMC3268876)

Zheng W*, Fu SX, Dydak U and Cowan DM (2011).Biomarkers of manganese intoxication.NeuroToxicology 32(1):1-8.

Zheng W*, Aschner M and Ghersi-Egea JF (2003). Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol.Appl.Pharmacol.192:1-11.

Park JD and Zheng W (2012). Human exposure and health effects of inorganic and elemental mercury (Review). J Preventive Med Public Health 45:344-352.

Aschner M, Nass R, Guilarte TR, Schneider JS and Zheng, W* (2007).Manganese: Recent advances in understanding its transport and neurotoxicity.Toxicol Appl Pharmacol 221(2):131-147.

Jiang Y and Zheng W* (2005).Cardiovascular toxicities upon manganese exposure.Cardiovasc.Toxicol.5:345-354.

Zheng W (2005).Introduction to the blood-CSF barrier.In: The Blood-Cerebrospinal Barrier, Zheng W and Chodobski A, Ed., CRC Press, New York.pp.3-7.

Li GJ and Zheng W* (2005). Regulation of neuroactive metals by the choroid plexus. In: The Blood-Cerebrospinal Barrier, Zheng W and Chodobski A, Ed., CRC Press, New York.pp.211-239.

Crossgrove JS and Zheng W* (2004).Manganese toxicity upon overexposure.NMR in Biomedicine 17(8):544-553.

Zheng, W (2001).Neurotoxicology of the brain barrier system: New implications.J Toxicol - Clin Toxicol 39(7):711-719.


II. Metals and Adult Neurogenesis and Repair

Fu X, O'Neal S, Hong L, Jiang W, and Zheng W* (2015). Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: Roles of copper and DMT1.Toxicol Sci 143(2):482-498.

Fu S, Jiang W, and Zheng W* (2015). Age-dependent accumulation of copper in brain subventricular zone (SVZ): Relationship to the expression of copper regulatory proteins in the SVZ and choroid plexus.Frontiers Mol Neurosci8:22.

Pushkar Y, Robison GA, Sullivan G, Fu X, Kohne M, Jiang W, Rohr S, Lai B, Marcus MA, Zakharova T and Zheng W (2013). Aging results in copper accumulations in subventricular astrocytes. Aging Cell 12(5):823-32. (PMCID: PMC3772960)


III. Mn, Cu and Fe in Parkinsonian Disorders

Bates CA, Fu S, Ysselstein D, Rochet JC and Zheng W* (2015). Expression and transport of a-synuclein at the blood-cerebrospinal fluid barrier and effects of manganese exposure.ADMET & DMPK3(1):15-33.

Fu X, Zhang YS, Jiang W, Monnot AD, Bates CA, and Zheng W* (2014). Regulation of copper transport crossing brain barrier systems by Cu-ATPases: Effect of manganese exposure. Toxicol Sci 139:432-451. (PMCID: PMC4064014)

O’Neal SL, Hong L, Fu S, Jiang W, Jones A, Nie L, and Zheng W* (2014). Manganese accumulation in bone following chronic exposure in rats: Steady-state concentration and half-life in bone. Tox Lett 229:93-100. (PMCID: PMC4126163)

O’Neal SL, Lee JW, Zheng W* and Cannon JR* (2014). Subchronic manganese exposure in rats is a neurochemical model of early manganese toxicity. Neurotoxicology 44:303-313. (NIHMSID#620692)

Bates CA and Zheng W* (2014). Transport of α-synuclein by brain barrier systems: Implications in Parkinson’s disease. Fluids Barriers CNS 11:17 (PMCID: PMC4120720)

Long ZY, Jiang YM, Li XR, Edden RAE., Xu J, Qin WP, Long LL, Murdoch J.B., Zheng W, and Dydak U (2014). Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers. PLOS ONE 9(2):e88220 (impact factor: 3.730) (PMCID: PMC3913772)

Hong L, Xu C, O’Neal SL, Bi HC, Huang M, Zheng W, and Zeng S (2014). Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain.Publications/Epapers/2014_Hong et al_ActaPharSinica_PAS-MDR1a.pdf Acta Pharmacologica Sinica 35: 1577-1585.

Long ZY, Jiang YM, Li XR, Fadel W,  Xu J, Yeh CL, Long LL, Luo HL, Harezlak J, Murdoch J.B., Zheng W, and Dydak U (2014). Vulnerability of welders to manganese exposure-A neuroimaging study. Neurotoxicology 45:285-292.

Robison GA, Zakharova T, Fu S, Jiang W, Fulper R, Barrea R, Zheng W and Pushkar Y (2013). X-ray fluorescence imaging of the hippocampal formation after manganese exposure. Metallomics 5:1554-1565 (PMID: 23999853) (PMCID: PMC3772960)

Zheng G, Chen JY and Zheng W* (2012). Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: Implication in manganese-induced neurotoxicity. Toxicol Appl Phamacol 260:285-293. (PMCID: PMC3336026)

Robison G, Zakharova T, Fu X, Jiang W, Fulper R, Barrea R, Marcus MA, Zheng W, and Pushkar Y (2012). X-ray fluorescence imaging: A new tool for studying manganese neurotoxicity. PLoS ONE 7(11): e48899. (PMCID: PMC3501493)

Monnot AD, Zheng G, and Zheng W* (2012). Mechanism of copper transport at the blood-cerebrospinal fluid barrier: Influence of iron deficiency. Exp Biol Med 237:327-333. (PMID: 22442359)

Monnot AD, Behl M, Ho S and Zheng W* (2011).Regulation of brain copper homeostasis by brain barrier systems: Effect of iron-overload or iron deficiency.Toxicol Appl Phamacol 256:249-257.

Hong L, Jiang W, Zheng W* and Zeng S (2011).HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues.J Pharmaceut Biomed Analysis 54:1101-1109.

Hong L, Jiang W, Pan H, Jiang YM, Zeng S and Zheng W* (2011).Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: In relation to their effectiveness in chelating brain manganese.Drug Met Disp 39(10):1904-1909.

Zheng W*, Jiang YM, Zhang YS, Jiang W, Wang X, and Cowan DM (2009).Chelation therapy of manganese intoxication by para-aminosalicylic acid (PAS) in Sprague-Dawley rats.NeuroToxicology 30: 240-248.

Choi BS and Zheng W* (2009).Copper transport to the brain by the blood-brain barrier and blood-CSF barrier.Brain Res 1248:14-21.

Wang XQ, Miller DS, and Zheng W* (2008).Intracellular trafficking of metal transporters in intact rat choroid plexus following in vitro treatment of manganese or iron.Toxicol Appl Pharmacol 230:167-174.

Kalia K, Jiang W and Zheng W* (2008).Manganese accumulates primarily in nuclei of cultured brain cells.NeuroToxicology 29(3):466-470.

Wang X, Li GJ and Zheng, W* (2006). Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res 1097(1):1-10.

Li GJ, Choi BS, Wang X, Liu J, Waalkes MP and Zheng, W* (2006).Molecular mechanism of distorted iron regulation in the choroids plexus and selected brain regional capillaries following in vivo manganese exposure.NeuroToxicology 27:737-744.

Li GJ, Zhao Q and Zheng, W* (2005). Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro.Toxicol Appl Pharmacol 205: 188- 200.

Deane R, Zheng W* and Zlokovic BV (2004).Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.J.Neurochem 88, 813-820.

Zheng W* and Zhao Q (2001). Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells.Brain Res 897:175-179.

Chen JY, Tsao G, Zhao Q and Zheng W* (2001).Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes.Toxicol Appl Pharmacol 175:160-168.

Zheng W*, Kim H and Zhao, Q (2000).Comparative toxicokinetics of manganese chloride and methylcyclo-pentadienyl Mn tricarbonyl in male Sprague-Dawley rats.Toxicol Sci 54:295-301.

Zheng W*, Zhao Q, Slavkovich V, Aschner M and Graziano H (1999).Alteration of iron homeostasis following chronic exposure to manganese in rats.Brain Res 833:125-132.

Zheng W*, Ren S and Graziano JH (1998). Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity.Brain Res 799:334-342.


IV. Pb, Beta-Amyloids and Alzheimer’s Disease

Fu X, Zeng AJ, Zheng W*, and Du Y (2014). Up-regulation of zinc transporter-2 in the blood-CSF barrier following lead exposure. Exp Biol Med 239:202-212. (PMCID: PMC3928640)

Gu HY, Zhong ZH, Jiang W, Du E, Dodel R, Farlow MR, Zheng W* and Du Y (2014). The role of choroid plexus in IVIG-induced beta-amyloid clearance.  Neuroscience  270:168-176.  (PMCID: PMC4035429)

Zheng G, Zhang J, Xu Y, Shen X, Song H, Jing J, Luo W, Zheng W*, and Chen J (2014). Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells. Toxicol Lett 225(1):110-118. (PMCID: PMC4127571)

Gu HY, Robison G, Barrea P, Hong L, Barrea R, Wei X, Farlow MR, Pushkar YN, Du YS, and Zheng W* (2012). Increased β-amyloid deposition in Tg-SWDI transgenic mouse brain following in vivo lead exposure.  Toxicol Letters 213:211-219. (PMCID: PMC3461595) (IF: 3.557)

Gu H, Wei X, Monnot AD, Fontanilla CV, Behl M, Farlow MR, Zheng W and Du YS (2011).Lead exposure increases levels of beta-amyloid in the CSF and brain tissues and inhibits LRP1 expression in APP transgenic mice.Neurosci Letters 490:16-20.

Behl M, Zhang YZ, Shi YZ and Zheng W* (2010).Lead-induced increase in beta-amyloid accumulation in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C activity.NeuroToxicology 31:524-532.

Behl M, Zhang Y, Monnot AD, Jiang W and Zheng W* (2009).Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low density lipoprotein receptor protein-1.Toxicol Appl Pharmacol 240:245-254

Crossgrove JS, Smith EL and Zheng W* (2007).Macromolecules involved in production and metabolism of beta-amyloid at the brain barriers.Brain Res.1138:187-195.

Crossgrove JS, Li GJ and Zheng W* (2005).The choroid plexus removes beta-amyloid from the cerebrospinal fluid.Exp Biol Med 230(10):771-776.(the Best Paper Award by Society for Experimental Biology and Medicine)

Zheng W*, Blaner WS and Zhao Q (1999).Inhibition by lead of production and secretion of transthyretin in the choroid plexus: Its relationship to thyroxine transport at the blood-CSF barrier.Toxicol Appl Pharmacol 155, 24-31.

Zhao Q, Slavkovich V and Zheng W* (1998).Lead exposure promotes translocation of protein kinase C activity in rat choroid plexus in vitro, but not in vivo.Toxicol Appl Pharmacol 149:99-106.

Zheng W*, Shen H, Blaner WS, Zhao Q, Ren X and Graziano JH (1996).Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: The role of the choroid plexus.Toxicol Appl Pharmacol 139:445-450.

Zheng W, Perry DF, Nelson DL and Aposhian HV (1991). Choroid Plexus protects cerebrospinal fluid against metals. FASEB J 5:2188-2193.


V. Studies on Human Subjects

Zhang Longlian, Lu L, Pan YJ, Ding CG, Xu DY, Huang CF, Pan XF and Zheng W* (2015). Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb.Environ Res140:10-17.

Louis ED, Galecki M, Benito-León J, Bermejo-Pareja F, Jiang W, Factor-Litvak P, and Zheng W (2014). Elevated blood harmane (1-Methyl-9H-Pyrido[3,4-B]indole) concentrations in Parkinson’s disease. Neurotoxicology 40:52-56 (PMCID: PMC3915406)

Louis ED, Factor-Litvak P, Michalec M, Jiang W, and Zheng W (2014). Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in dystonia cases vs. controls. Neurotoxicology 44:110-113.

Louis ED, Benito-Leon J, Moreno-García S; Vega S, Romero JP, Bermejo-Pareja F, Gerbin M, Viner AS, Factor-Litvak P, Jiang W, and Zheng W (2013). Blood harmane (1-methyl-9h-pyrido[3,4-B]indole) concentration in essential tremor cases in Spain. Neurotoxicology 34:264-268. (PMCID: PMC3556362)

Louis ED, Factor-Litvak P, Liu X, Vonsattel JPG, Galecki M, Jiang W, Zheng W (2013). Elevated brain harmane (1-methyl-9H-pyrido[3,4-b]indole) in essential tremor cases vs. controls.Neurotoxicology 38:131-135. (PMCID: PMC3784356).

Li H, Zhou DL, Zhang Q, Feng CY, Zheng W, He KP, Lan YJ (2013). Vanadium exposure-induced neurobehavioral alterations among Chinese workers. Neurotoxicology 36:49-54. (PMCID: PMC4160152)

Louis ED, Jiang W, Gerbin M, Viner AS, Factor-Litvak P, Zheng W (2012). Blood harmane (1-methyl-9h-pyrido[3,4-b]indole) concentrations in essential tremor: Repeat observation in cases and controls in New York. J Toxicol Environ Health. Part A 75:673-683. (PMCID: PMC3412610)

Louis ED, Factor-Litvak P, Gerbin M, Slavkovich V, Graziano JH, Jiang W, and Zheng W (2011). Blood harmane, blood lead, and severity of hand tremor: Evidence of additive effects. Neurotoxicology 32(2):227-232.  (PMCID: PMC3073713)

Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu SG, Fu X, Long ZY, Mo XA, Meier D, Harezlak J, Aschner M, Murdoch J and Zheng W (2011).In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese.Env Health Persp 119:219-224.

Louis ED and Zheng W (2010).Beta-carboline alkaloids and essential Tremor: Exploring the environmental determinants of one of the most prevalent neurological diseases.TSW The Scientific World Journal 10:1783-1794.

Louis ED, Jiang W, Gerbin M, Mullaney MMM and Zheng W* (2010).Relationship between blood harmane and harmine concentrations in familial essential tremor, sporadic essential tremor and controls.NeuroToxicology 31: 674-679.

Long LL, Li XR, Huang ZK, Jiang YM and Zheng W* (2009). Relationship Between Changes in Brain MRI and 1H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation. Exp Biol Med 234:1075-1085.

Cowan DM, Zheng W*, Zou Y, Shi XJ, Chen J, Rosenthal FS and Fan QY (2009).Manganese exposure among smelting workers: Relationship between blood manganese-iron ratio and early onset neurobehavioral alternations.Neurotoxicology 30:1214-1222.

Cowan DM, Fan QY, Zou Y, Shi XJ, Chen J, Rosenthal FS, Aschner M, and Zheng W* (2009).Manganese exposure among smelting workers: Blood manganese-iron ratio as a novel tool for manganese exposure assessment.Biomarkers 14(1): 3-16.

Wang DX, Du XQ, and Zheng W* (2008).Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders.Toxicol Letters 176:40-47.

Louis ED, Jiang W, Pellegrino KM, Rios E, Factor-Litvak P, Henchcliffe C and Zheng W (2008).Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor.NeuroToxicology 29: 294-300.

Jiang YM, Long LL, Zhu XY, Zheng H, Fu X, Ou SY, Wei DL, Zhou HL and Zheng W* (2008).Evidence for altered hippocampal volume and metabolites in workers occupationally exposed to lead: A study by magnetic resonance imaging and 1H magnetic resonance spectroscopy.Toxicol Letters 181: 118-125.

Louis ED, Zheng W, Mao XL and Shungu, D (2007).Blood harmane concentration is correlated with cerebellar metabolism in essential tremor: A pilot study.Neurology 69:515-520.

Louis ED, Zheng W, Jiang W, Bogen KT and Keating, GA (2007).Quantification of the neurotoxic beta-carboline harmane in pan-fried meat samples and correlation with level of doneness.J.Toxicol.Env.Health 70:1014-1019.

Jiang YM, Zheng W*, Long LL, Zhao WJ, Li XG, Mo XA, Lu JP, Fu X, Li WM, Liu SF, Long QY, Huang JL and Pira, E (2007).Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure.NeuroToxicology 28:126-135.

Jiang YM, Mo XA, Du FQ, Fu X, Zhu XY, Gao HY, Xie JL, Liao FL, Pira E and Zheng, W* (2006).Effective Treatment of Manganese-Induced Occupational Parkinsonism with PAS-Na: A Case of 17-Year Follow-Up Study.J.Occup.Env.Med.48:644-649.

Lu L, Zhang LL, Li GJ, Guo W, Liang W and Zheng W* (2005). Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders. NeuroToxicology 26(2): 257-265.

Louis ED, Zheng W, Applegate L, Shi L, and Factor-Litvak P (2005). Blood harmane concentrations and dietary protein consumption in essential tremor.Neurology 65:391-396.

Li GJ, Zhang L, Lu L, Wu P and Zheng W* (2004).Occupational exposure to welding fume among welders: alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status.J.Occup.Environ.Med.46(3):241-248.

Louis ED, Zheng W, Jurewicz EC, Watner D, Chen J, Factor-Litvak P and Parides M (2002).Elevation of blood beta-carboline alkaloids in essential tremor.Neurology.59:1940-1944.

Zheng W*, Lu YM, Lu GY, Zhao Q, Cheung O and Blaner WS (2001).Transthyretin, thyroxin, and retinol-binding protein in human cerebrospinal fluid: Effect of lead exposure.Toxicol Sci 61:107-114.


VI. BBB, BCB, Methods and Others

Liu Y, Byrne P, Wang H, Koltick D, Zheng W, and Nie LH (2014). A compact DD neutron generator–based NAA system to quantify manganese (Mn) in bone in vivo.Publications/Epapers/2014_Liu et al_Physiol Meas_NAA-MnBn.pdf Physiol Meas35:1899–1911.

Monnot AD, and Zheng W* (2012). Culture of choroidal plexus epithelial cells and in vitro model of blood-CSF barrier. Methods Mol Biol (Epithelial Cell Culture Protocols) 945:13-29. (PMCID: PMC3628876)

Kanoski SE, Zhang Y, Zheng W and Davidson TL (2010).The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.J Alzheimer's Disease 21(1):207-219.

Shi LZ and Zheng W* (2005).Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study.Brain Res 1057:37-48.

Zheng W* and Segal MB (2005).In situ techniques used in the blood-CSF barrier research.In: The Blood-Cerebrospinal Barrier, Zheng W and Chodobski A, Ed., CRC Press, New York.pp.541-551.

Zheng W* and Zhao Q (2002).Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus.Brain Res.958:371-380.

Zheng W*, Zhao Q and Graziano JH (1998).Primary culture of rat choroidal epithelial cells: a model for in vitro study of the blood-cerebrospinal fluid barrier.In Vitro Cell Biol Dev 34(1), 40-45.

Zheng W, Winter SM, Mayersohn M, Bishop JM and Sipes IG (1993).Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice.Drug Met Disp 21(6):1091-1097.

Zheng W, Maiorino RM, Brendel K and Aposhian HV (1990).Determination and metabolism of dithiol chelating agents: VII.Biliary excretion of dithiols and their interactions with cadmium and metallothionein.Fundam Appl Toxicol 14:598-607.